Association of Canonical Wnt/β-Catenin Pathway and Type 2 Diabetes: Genetic Epidemiological Study in Han Chinese

• Published in: Nutrients Vol. 7; no. 6; pp. 4763 - 4777
• Main Authors: Wang, Jinjin, Zhao, Jingzhi, Zhang, Jianfeng, Luo, Xinping, Gao, Kaiping, Zhang, Ming, Li, Linlin, Wang, Chongjian, Hu, Dongsheng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 15.06.2015
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; anthropometric measurements; Asian Continental Ancestry Group - genetics; beta Catenin - genetics; beta Catenin - metabolism; Body Mass Index; Case-Control Studies; China; Chinese people; Diabetes Mellitus, Type 2 - genetics; epidemiological studies; Female; gene interaction; genes; Genetic Predisposition to Disease; genotyping; Genotyping Techniques; glucagon; Glucagon - genetics; Glucagon - metabolism; Haplotypes; Humans; Linkage Disequilibrium; lipids; Logistic Models; Low Density Lipoprotein Receptor-Related Protein-5 - genetics; Low Density Lipoprotein Receptor-Related Protein-5 - metabolism; Male; Middle Aged; noninsulin-dependent diabetes mellitus; patients; Polymorphism, Single Nucleotide; regression analysis; risk factors; risk reduction; signal transduction; single nucleotide polymorphism; Transcription Factor 7-Like 2 Protein - genetics; Transcription Factor 7-Like 2 Protein - metabolism; transcription factors; Wnt Signaling Pathway; Young Adult; China; Chinese; WNT signaling pathway; type 2 diabetes; polymorphisms

We aimed to investigate the associations of polymorphisms in Canonical Wnt/β-catenin pathway (WNT) signaling genes (including low-density lipoprotein-related protein 5 [LRP5] and transcription factor 7-like 2 [TCF7L2] gene) and the downstream gene glucagon (GCG) and risk of type 2 diabetes mellitus...