A Broad-Host-Range Tailocin from Burkholderia cenocepacia

• Published in: Applied and environmental microbiology Vol. 83; no. 10; p. E03414
• Main Authors: Yao, Guichun W., Duarte, Iris, Le, Tram T., Carmody, Lisa, LiPuma, John J., Young, Ry, Gonzalez, Carlos F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.05.2017
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotics; Bacteria; Bacteriocins - chemistry; Bacteriocins - metabolism; Bacteriocins - pharmacology; Biosynthesis; Burkholderia; Burkholderia cenocepacia - chemistry; Burkholderia cenocepacia - genetics; Burkholderia cenocepacia - metabolism; Burkholderia cepacia; Burkholderia cepacia complex - drug effects; Burkholderia cepacia complex - growth & development; Chromatography; Chromosome 1; Coding; Cystic fibrosis; Deletion mutant; Derivatives; Enzymes; Gene deletion; Genes; Genetics and Molecular Biology; Genome, Bacterial; Genome, Viral; Genomes; Glucose; Gram-negative bacteria; Host range; Host Specificity; Humans; Lipopolysaccharides; Liquid chromatography; Mass Spectrometry; Mass spectroscopy; Molecular Structure; Pathogens; Phages; Proteins; Pseudomonas; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - growth & development; Synteny; Transcription; broad host range; Burkholderia cenocepacia; receptor; LPS; tailocin

The Burkholderia cepacia complex (Bcc) consists of 20 closely related Gram-negative bacterial species that are significant pathogens for persons with cystic fibrosis (CF). Some Bcc strains are highly transmissible and resistant to multiple antibiotics, making infection difficult to treat. A tailocin...