The accuracy of combined cytopathologic and flow cytometric analysis of fine-needle aspirates of lymph nodes
We studied flow cytometry in 156 fine-needle aspirations (FNAs) of lymph nodes performed between June 1993 and September 1998. Information from flow cytometry was combined with cytomorphologic evaluation, and the diagnosis determined by using combined modalities was compared with tissue biopsy resul...
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Published in | American journal of clinical pathology Vol. 114; no. 1; pp. 18 - 28 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
American Society of Clinical Pathologists
01.07.2000
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Abstract | We studied flow cytometry in 156 fine-needle aspirations (FNAs) of lymph nodes performed between June 1993 and September 1998. Information from flow cytometry was combined with cytomorphologic evaluation, and the diagnosis determined by using combined modalities was compared with tissue biopsy results or clinical follow-up. In 74 cases, a combined cytopathologic-flow cytometric diagnosis of lymphoma was made; histologic material was available for 52 patients; in no case was a benign process found. The lymphoma grade assigned agreed with histopathologic findings in 45 of 48 cases with a specific cytologic diagnosis. Treatment was initiated on the basis of the FNA alone for 17 of 52 patients with a history of lymphoma and in 22 additional patients with no follow-up biopsy. Among 71 cases in which the diagnosis using both modalities was benign, the only false-negative was 1 case of Hodgkin disease. Of the 156 cases, 11 were considered atypical or suggestive of lymphoma; biopsies from 8 of 10 patients revealed lymphoma. A combination of flow cytometry and cytomorphology of cells obtained by FNA of lymph nodes can distinguish between benign and malignant lymphoid infiltrates and support a diagnosis of lymphoma that permits definitive therapy in most cases. |
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AbstractList | We studied flow cytometry in 156 fine-needle aspirations (FNAs) of lymph nodes performed between June 1993 and September 1998. Information from flow cytometry was combined with cytomorphologic evaluation, and the diagnosis determined by using combined modalities was compared with tissue biopsy results or clinical follow-up. In 74 cases, a combined cytopathologic-flow cytometric diagnosis of lymphoma was made; histologic material was available for 52 patients; in no case was a benign process found. The lymphoma grade assigned agreed with histopathologic findings in 45 of 48 cases with a specific cytologic diagnosis. Treatment was initiated on the basis of the FNA alone for 17 of 52 patients with a history of lymphoma and in 22 additional patients with no follow-up biopsy. Among 71 cases in which the diagnosis using both modalities was benign, the only false-negative was 1 case of Hodgkin disease. Of the 156 cases, 11 were considered atypical or suggestive of lymphoma; biopsies from 8 of 10 patients revealed lymphoma. A combination of flow cytometry and cytomorphology of cells obtained by FNA of lymph nodes can distinguish between benign and malignant lymphoid infiltrates and support a diagnosis of lymphoma that permits definitive therapy in most cases. |
Author | NICOL, T. L ROSENTHAL, D. L BOROWITZ, M. J SILBERMAN, M |
Author_xml | – sequence: 1 givenname: T. L surname: NICOL fullname: NICOL, T. L organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United States – sequence: 2 givenname: M surname: SILBERMAN fullname: SILBERMAN, M organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United States – sequence: 3 givenname: D. L surname: ROSENTHAL fullname: ROSENTHAL, D. L organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United States – sequence: 4 givenname: M. J surname: BOROWITZ fullname: BOROWITZ, M. J organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United States |
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Keywords | Performance evaluation Human Flow cytometry Associated technique Lymph node Benign lymphoid hyperplasia Immunocytochemistry Malignant hemopathy Aspiration punction Lymphoma Differential diagnostic Pathology Fine needle Lymphoproliferative syndrome Cytopathology Diagnosis Technique |
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References | Katz (6) 1987; 3 O'Hara (11) 1985; 1 Dunphy (34) 1997; 16 Cibas (19) 1987; 88 Hanson (14) 1994; 101 Stewart, FW (3) 1933; 9 Saleh (22) 1995; 13 Zander (33) 1994; 101 Layfield, LJ (31) 1996; 4 Picker (8) 1987; 128 Joensuu (21) 1988; 154 Cha (27) 1996; 4 Sneige (9) 1990; 34 Lovett (25) 1984; 50 Johnson (24) 1987; 11 Colvin (26) 1987; 111 Harris (16) 1994; 84 Martin (7) 1984; 82 Chernoff (28) 1992; 21 Saddik (29) 1997; 16 Borowitz (4) 1981; 25 Katz, RL (10) 1997 Forkner, CE (1) 1927; 40 Tarantino (32) 1998; 176 Clatch (13) 1996; 105 Young (18) 1998; 84 Guthrie, CG (2) 1921; 32 Robins (15) 1994; 101 Katz (17) 1995; 12 Hanson (23) 1989; 3 Ramzy (5) 1985; 1 20 Suhrland (12) 1991; 9 MacCallum (30) 1996; 25 |
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SubjectTerms | Biological and medical sciences Biopsy, Needle Evaluation Studies as Topic False Negative Reactions Flow Cytometry - standards Hematology Hodgkin Disease - pathology Humans Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Lymph Nodes - pathology Lymphoma - pathology Medical sciences Pathology - methods Pathology - standards Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Retrospective Studies |
Title | The accuracy of combined cytopathologic and flow cytometric analysis of fine-needle aspirates of lymph nodes |
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