Cancer invasion and metastasis: Insights from murine pubertal mammary gland morphogenesis

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 8; p. 130375
• Main Authors: Githaka, John Maringa, Pirayeshfard, Leila, Goping, Ing Swie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2023
• Subjects: Animals; Cancer invasion; carcinogenesis; Cell Transformation, Neoplastic - genetics; Epithelial Cells - pathology; epithelium; Gene Expression Profiling; Humans; Mammary gland morphogenesis; mammary glands; Mammary Glands, Human; Metastasis; Mice; migratory behavior; morphogenesis; Morphogenesis - genetics; mortality; Puberty phenotype; transcriptome; Transcriptomics; Cancer invasion; Puberty phenotype; Metastasis; Transcriptomics; Mammary gland morphogenesis

Cancer invasion and metastasis accounts for the majority of cancer related mortality. A better understanding of the players that drive the aberrant invasion and migration of tumors cells will provide critical targets to inhibit metastasis. Postnatal pubertal mammary gland morphogenesis is characteri...