The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

• Published in: Frontiers in aging neuroscience Vol. 16; p. 1347987
• Main Authors: Adamu, Alhamdu, Li, Shuo, Gao, Fankai, Xue, Guofang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 12.04.2024; Frontiers Media S.A
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; Brain research; Cell therapy; Central nervous system; Chemokines; Chronic illnesses; Cytokines; Disease; Glial cells; Immune response; Immune response (cell-mediated); Immune system; Infections; Inflammation; Injuries; Movement disorders; Multiple sclerosis; Nanoparticles; Neurodegeneration; neurodegenerative disease; Neurodegenerative diseases; neuroinflammation; Neurological disorders; Neuronal-glial interactions; Parkinson's disease; Reactive nitrogen species; Reactive oxygen species; Therapeutic targets; Trauma; Viral infections; neurodegenerative disease; Alzheimer’s disease; neuroinflammation; Parkinson’s disease; central nervous system

Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen a...