Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease

• Published in: Journal of molecular neuroscience Vol. 72; no. 2; pp. 173 - 186
• Main Authors: Girotra, Pragya, Behl, Tapan, Sehgal, Aayush, Singh, Sukhbir, Bungau, Simona
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2022; Springer Nature B.V
• Subjects: Alzheimer's disease; Biomarkers; Biomedical and Life Sciences; Biomedicine; Brain; Brain-derived neurotrophic factor; Cell Biology; Cell surface; Cerebral cortex; Cognitive ability; Degeneration; Dementia; Dementia disorders; Fibers; Growth factors; Kinases; Nerve growth factor; Neurochemistry; Neurodegeneration; Neurodegenerative diseases; Neurofibrillary tangles; Neurology; Neurosciences; Neurotrophic factors; Neurotrophin 3; Neurotrophin 4; Patients; Plaques; Protein-tyrosine kinase; Proteins; Proteomics; Signal transduction; TrkB receptors; Tyrosine; Neurotrophin; Brain-derived neurotrophic factor; Tyrosine receptor kinase B; Amyloid precursor protein; Tau proteins; Amyloid-beta

Brain-derived neurotrophic factor (BDNF), or abrineurin, is a member of the neurotrophin family of growth factors that acts on both the central and peripheral nervous systems. BDNF is also well known for its cardinal role in normal neural maturation. It binds to at least two receptors at the cell su...