Compensatory motor network connectivity is associated with motor sequence learning after subcortical stroke

• Published in: Behavioural brain research Vol. 286; pp. 136 - 145
• Main Authors: Wadden, Katie P., Woodward, Todd S., Metzak, Paul D., Lavigne, Katie M., Lakhani, Bimal, Auriat, Angela M., Boyd, Lara A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2015
• Subjects: Brain - physiopathology; Brain Mapping; Constrained principal component analysis; Female; Functional connectivity; Functional magnetic resonance imaging; Humans; Learning - physiology; Magnetic Resonance Imaging; Male; Middle Aged; Motor sequence learning; Motor Skills - physiology; Neural Pathways - physiopathology; Principal Component Analysis; Stroke; Stroke - physiopathology; Stroke - psychology; Functional connectivity; Functional magnetic resonance imaging; Stroke; Constrained principal component analysis; Motor sequence learning
• ISSN: 0166-4328; 1872-7549; 1872-7549
• DOI: 10.1016/j.bbr.2015.02.054

•We evaluated brain connectivity during motor tracking in healthy and stroke participants.•Healthy subjects demonstrated connectivity within a widely disturbed motor network.•A mask of the motor network was created to assess connectivity for the stroke group.•The connectivity within a smaller motor network correlated with motor performance in the stroke group.•Motor network connectivity may be a predictor of motor learning and recovery following stroke. Following stroke, functional networks reorganize and the brain demonstrates widespread alterations in cortical activity. Implicit motor learning is preserved after stroke. However the manner in which brain reorganization occurs, and how it supports behavior within the damaged brain remains unclear. In this functional magnetic resonance imaging (fMRI) study, we evaluated whole brain patterns of functional connectivity during the performance of an implicit tracking task at baseline and retention, following 5 days of practice. Following motor practice, a significant difference in connectivity within a motor network, consisting of bihemispheric activation of the sensory and motor cortices, parietal lobules, cerebellar and occipital lobules, was observed at retention. Healthy subjects demonstrated greater activity within this motor network during sequence learning compared to random practice. The stroke group did not show the same level of functional network integration, presumably due to the heterogeneity of functional reorganization following stroke. In a secondary analysis, a binary mask of the functional network activated from the aforementioned whole brain analyses was created to assess within-network connectivity, decreasing the spatial distribution and large variability of activation that exists within the lesioned brain. The stroke group demonstrated reduced clusters of connectivity within the masked brain regions as compared to the whole brain approach. Connectivity within this smaller motor network correlated with repeated sequence performance on the retention test. Increased functional integration within the motor network may be an important neurophysiological predictor of motor learning-related change in individuals with stroke.