density of small tight junction pores varies among cell types and is increased by expression of claudin-2

• Published in: Journal of cell science Vol. 121; no. 3; pp. 298 - 305
• Main Authors: Van Itallie, Christina M, Holmes, Jennifer, Bridges, Arlene, Gookin, Jody L, Coccaro, Maria R, Proctor, William, Colegio, Oscar R, Anderson, James M
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.02.2008
• Subjects: Animals; Biological Transport, Active; Caco-2 Cells; Cell Line; Claudin-4; Claudins; Dogs; Humans; LLC-PK1 Cells; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - metabolism; Particle Size; Polyethylene Glycols - chemistry; Polyethylene Glycols - pharmacokinetics; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Swine; Tight Junctions - metabolism; Tight Junctions - ultrastructure; Transfection

Epithelial tight junctions contain size- and charge-selective pores that control the paracellular movement of charged and noncharged solutes. Claudins influence the charge selectivity and electrical resistance of junctions, but there is no direct evidence describing pore composition or whether pore...