Partial Liquid Ventilation in Adult Patients with Acute Respiratory Distress Syndrome

• Published in: American journal of respiratory and critical care medicine Vol. 173; no. 8; pp. 882 - 889
• Main Authors: Kacmarek, Robert M, Wiedemann, Herbert P, Lavin, Philip T, Wedel, Mark K, Tutuncu, Ahmet S, Slutsky, Arthur S
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.04.2006; American Lung Association; American Thoracic Society
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Catheters; Clinical death. Palliative care. Organ gift and preservation; Clinical trials; Dose-Response Relationship, Drug; Emergency and intensive respiratory care; Female; Fluorocarbons - administration & dosage; Fluorocarbons - therapeutic use; Follow-Up Studies; Gases; Humans; Instillation, Drug; Intensive care medicine; Liquid Ventilation - methods; Lungs; Male; Medical sciences; Middle Aged; Mortality; Perfluorocarbons; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - mortality; Respiratory Distress Syndrome, Adult - therapy; Retrospective Studies; Suctioning; Survival Rate; Treatment Outcome; Ventilation; Ventilators; Human; Intensive care; Liquid ventilation; Respiratory disease; acute respiratory distress syndrome; Respiratory distress; Mechanical ventilation; partial liquid ventilation; Resuscitation

Despite recent clinical trials demonstrating improved outcome in acute respiratory distress syndrome (ARDS), mortality remains high. Partial liquid ventilation (PLV) using perfluorocarbons has been shown to improve oxygenation and decrease lung injury in various animal models. To determine if PLV wo...