Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats

• Published in: Brain Structure and Function Vol. 226; no. 7; pp. 2169 - 2180
• Main Authors: Otsuka, Shotaro, Sakakima, Harutoshi, Tani, Akira, Nakanishi, Kazuki, Takada, Seiya, Norimatsu, Kosuke, Maejima, Hiroshi, Maruyama, Ikuro
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2021; Springer Nature B.V
• Subjects: Animals; Apoptosis; Biomedical and Life Sciences; Biomedicine; Brain; Brain-Derived Neurotrophic Factor; Cell Biology; Cerebral blood flow; Disease Models, Animal; Exercise; Glial fibrillary acidic protein; Hypoxia-inducible factor 1a; Infarction, Middle Cerebral Artery; Ischemia; Ischemic Stroke; Neurological diseases; Neurology; Neuronal-glial interactions; Neuroprotection; Neurosciences; Original Article; Rats; Rats, Sprague-Dawley; Sensorimotor system; Stroke; Neuroprotection; Apoptotic activity; Exercise cessation; HIF-1α; Preconditioning exercise; BDNF

Preconditioning exercise prior to stroke exerts neuroprotection, which is an endogenous strategy that leads the brain cells to express several intrinsic factors and inhibits their apoptosis. However, it is unclear how long these benefits last after exercise cessation. The aim of this study was to in...