Polyadenylation of ribosomal RNA in human cells

• Published in: Nucleic acids research Vol. 34; no. 10; pp. 2966 - 2975
• Main Authors: Slomovic, Shimyn, Laufer, David, Geiger, Dan, Schuster, Gadi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2006; Oxford Publishing Limited (England)
• Subjects: Cell Line, Tumor; Expressed Sequence Tags; Humans; Oligonucleotide Probes; Poly A - analysis; Polyadenylation; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Ribosomal - chemistry; RNA, Ribosomal - metabolism; RNA, Ribosomal, 18S - analysis; RNA, Ribosomal, 18S - chemistry; RNA, Ribosomal, 18S - metabolism; RNA, Ribosomal, 28S - analysis; RNA, Ribosomal, 28S - chemistry; RNA, Ribosomal, 28S - metabolism

The addition of poly(A)-tails to RNA is a process common to almost all organisms. In eukaryotes, stable poly(A)-tails, important for mRNA stability and translation initiation, are added to the 3′ ends of most nuclear-encoded mRNAs, but not to rRNAs. Contrarily, in prokaryotes and organelles, polyade...