Membrane composition modulates the interaction between a new class of antineoplastic agents deriving from aromatic 2-chloroethylureas and lipid bilayers: a solid-state NMR study

• Published in: Chemistry and physics of lipids Vol. 146; no. 2; pp. 125 - 135
• Main Authors: Cronier, Francis, Patenaude, Alexandre, C.-Gaudreault, René, Auger, Michèle
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.04.2007
• Subjects: Antineoplastic Agents - chemistry; Arylchloroethylureas; Cardiolipin; Endoplasmic reticulum; Lipid Bilayers; Magnetic Resonance Spectroscopy - methods; Mitochondria; Model membranes; Solid-state NMR spectroscopy; Urea - chemistry; Model membranes; Mitochondria; Cardiolipin; Solid-state NMR spectroscopy; Endoplasmic reticulum; Arylchloroethylureas

We have investigated the interaction between a new class of antineoplastic agents derived from arylchloroethylureas (CEU) with three different model membranes by 31P and 2H solid-state NMR spectroscopy. First, we have prepared model membranes that mimic the mitochondrial inner (Mito IM) and outer (M...