Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta

• Published in: Bone (New York, N.Y.) Vol. 19; no. 6; pp. 575 - 579
• Main Authors: Saban, J., Zussman, M.A., Havey, R., Patwardhan, A.G., Schneider, G.B., King, D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.12.1996; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Biomechanical Phenomena; Biomechanics; Bone and Bones - injuries; Bone and Bones - physiopathology; Bones; Diaphyses - pathology; Disease Models, Animal; Diseases of the osteoarticular system; Female; Femoral Fractures - genetics; Femoral Fractures - physiopathology; Heterozygote; Male; Malformations and congenital and or hereditary diseases involving bones. Joint deformations; Medical sciences; Mice; Mice, Mutant Strains; oim mice; Osteogenesis imperfecta; Osteogenesis Imperfecta - etiology; Osteogenesis Imperfecta - genetics; Phenotype; Tibia - pathology; Biomechanics; Osteogenesis imperfecta; Bones; oim mice; Heterozygozity; Animal model; Procollagen; Pathophysiology; Rodentia; Diseases of the osteoarticular system; Mechanical properties; Histology; Genetic disease; Pathology; Vertebrata; Phenotype; Mammalia; Gene; Mouse; Collagen; Mutation; Bone; Osteochondrodysplasia

The oim strain of mice is one of several rodent models that exhibit an osteogenesis imperfecta (OI) phenotype. These mice have a mutation in the gene encoding α-2 chain of type I procollagen that prevents proper assembly of this propeptide with α-1 propeptides. Homozygous oim mice experience multipl...