Evaluation of a novel biocompatible magnetic nanomedicine based on beta-cyclodextrin, loaded doxorubicin-curcumin for overcoming chemoresistance in breast cancer

• Published in: Artificial cells, nanomedicine, and biotechnology Vol. 46; no. sup2; pp. 207 - 216
• Main Authors: Rastegar, Roghayeh, Akbari Javar, Hamid, Khoobi, Mehdi, Dehghan Kelishadi, Poua, Hossein Yousefi, Gholam, Doosti, Mahmoud, Hossien Ghahremani, Mohammad, Shariftabrizi, Ahmad, Imanparast, Fatemeh, Gholibeglu, Elham, Gholami, Mahdi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2018; Taylor & Francis Ltd
• Subjects: Accumulation; Anticancer properties; Biocompatibility; Breast cancer; Breast carcinoma; Cancer; Chemoresistance; Confocal microscopy; Curcumin; Cyclodextrins; Cytotoxicity; Doxorubicin; Electrophoresis; enhanced permeability and retention effect; Gel electrophoresis; Glycoproteins; Hydroxyapatite; iron oxide nanoparticle; Magnetic permeability; Nanocomposites; nanomedicine; Nanoparticles; Nanotechnology; P-Glycoprotein; Permeability; Pharmacology; protein corona; Proteins; Sodium dodecyl sulfate; Sodium lauryl sulfate; Toxicity testing; Tumors; β-Cyclodextrin; nanomedicine; iron oxide nanoparticle; Chemoresistance; enhanced permeability and retention effect; protein corona

Codelivery of chemo-sensitizers with chemotherapeutics using combo nanomedicine is a promising platform for overcoming chemoresistance in breast cancer. However, tumor accumulation of nano-carriers based on enhanced permeability and retention (EPR) effect is confounded by heterogeneity in tumor micr...