Bile acids and the gut microbiota: metabolic interactions and impacts on disease

• Published in: Nature reviews. Microbiology Vol. 21; no. 4; pp. 236 - 247
• Main Authors: Collins, Stephanie L., Stine, Jonathan G., Bisanz, Jordan E., Okafor, C. Denise, Patterson, Andrew D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2023; Nature Publishing Group
• Subjects: 631/154/309/2144; 631/326/2565/2134; 631/326/41; 631/92/320; Acids; Antibiotics; Bacteria; Bacteria - metabolism; Bile; Bile acids; Bile Acids and Salts - metabolism; Biomedical and Life Sciences; Colitis; Community structure; Composition; Drug development; Gastrointestinal Microbiome; Gut microbiota; Humans; Infectious Diseases; Intestinal microflora; Life Sciences; Medical Microbiology; Metabolism; Microbiology; Microbiomes; Microbiota; Parasitology; Review Article; Signal Transduction; Structure-function relationships; Virology

Despite decades of bile acid research, diverse biological roles for bile acids have been discovered recently due to developments in understanding the human microbiota. As additional bacterial enzymes are characterized, and the tools used for identifying new bile acids become increasingly more sensit...