Differential effects of MDMA and scopolamine on working versus reference memory in the radial arm maze task

• Published in: Neurobiology of learning and memory Vol. 93; no. 2; pp. 151 - 156
• Main Authors: Kay, C., Harper, D.N., Hunt, M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2010; Elsevier; Elsevier BV
• Subjects: Analysis of Variance; Animals; Behavioral psychophysiology; Biological and medical sciences; Cholinergic Antagonists - administration & dosage; Cholinergic Antagonists - pharmacology; Cognition & reasoning; Dose-Response Relationship, Drug; Drug abuse; Eight-arm radial maze; Fundamental and applied biological sciences. Psychology; Male; Maze Learning - drug effects; MDMA; Memory; Memory - drug effects; Memory, Short-Term - drug effects; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage; N-Methyl-3,4-methylenedioxyamphetamine - pharmacology; Neurology; Neuropsychological Tests; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Reference memory; Rodents; Scopolamine; Scopolamine Hydrobromide - administration & dosage; Scopolamine Hydrobromide - pharmacology; Serotonin Agents - administration & dosage; Serotonin Agents - pharmacology; Time Factors; Working memory; Eight-arm radial maze; Reference memory; Rats; Scopolamine; Working memory; MDMA; Hyoscine; Rat; Rodentia; Alkaloid; Anticholinergic agent; Vertebrata; Mammalia; Animal; Arm; Comparative study

Previous research has suggested that the disruption to memory-task performance seen following acute exposure to 3,4-methylenedioxymethaphemtamine (MDMA) with rats might best be characterized as reference memory impairment rather than a working memory impairment. The current study specifically compar...