Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration

• Published in: Biological chemistry Vol. 401; no. 9; pp. 1031 - 1039
• Main Authors: Ren, Mengmeng, Yang, Xin, Bie, Juntao, Wang, Zhe, Liu, Minghui, Li, Yutong, Shao, Genze, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 27.08.2020; Walter de Gruyter GmbH
• Subjects: Adenine; Biological activity; cancer; Cell growth; Cell migration; Cell proliferation; Citrate synthase; Colon; Colon cancer; Colorectal cancer; Enzymatic activity; NAD; Nicotinamide; Nicotinamide adenine dinucleotide; SIRT5; Substrates; succinylation; Tricarboxylic acid cycle; Tumorigenesis; citrate synthase; SIRT5; cancer; succinylation

Citrate synthase (CS), the rate-limiting enzyme in the tricarboxylic acid (TCA) cycle catalyzes the first step of the cycle, namely, the condensation of oxaloacetate and acetyl-CoA to produce citrate. The expression and enzymatic activity of CS are altered in cancers, but posttranslational modificat...