Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation - D'Annessa, Ilda; Gandaglia, Anna; Brivio, Elena; Stefanelli, Gilda; Frasca, Angelisa; Landsberger, Nicoletta; Di Marino, Daniele (Biochimica et biophysica acta. General subjects, 2018)
Keywords: Amino Acid Substitution; aspartic acid; binding capacity; DNA; DNA - chemistry; DNA - genetics; DNA - metabolism; DNA binging domain; DNA-binding domains; Docking; epigenetics; Female; females; genes; genotype; Humans; MeCP2 Methyl-CpG-binding protein 2; Methyl-CpG-Binding Protein 2 - chemistry; Methyl-CpG-Binding Protein 2 - genetics; Methyl-CpG-Binding Protein 2 - metabolism; missense mutation; molecular dynamics; Molecular Dynamics Simulation; Mutation, Missense; pathogenicity; phenotype; phosphates; phosphorylation; prediction; Protein Domains; Rett causing mutation; Rett Syndrome; transcription (genetics); transcription factors; Docking; DNA binging domain; Molecular dynamics simulation; Rett causing mutation; MeCP2 Methyl-CpG-binding protein 2; Rett syndrome