Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination

• Published in: Vaccines (Basel) Vol. 13; no. 2; p. 140
• Main Authors: Nishiyama, Ayae, Nogimori, Takuto, Masuta, Yuji, Matsuura, Tomoka, Kase, Tetsuo, Kondo, Kyoko, Ohfuji, Satoko, Nakagama, Yu, Kaku, Natsuko, Nakagama, Sachie, Nitahara, Yuko, Takahashi, Yoshimasa, Kakeya, Hiroshi, Kido, Yasutoshi, Fukushima, Wakaba, Yamamoto, Takuya
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.01.2025; MDPI
• Subjects: Antibodies; antibody-dependent cellular cytotoxicity; antibody-dependent cellular phagocytosis; Antigens; Avian flu; Cloning; Control; Cross-protection; Cytotoxicity; Domains; Dosage and administration; Enzymes; Epitopes; Evaluation; Health aspects; Hemagglutinins; Immune response; Immunization; Immunoglobulin G; Infections; Influenza; Influenza A; Influenza vaccines; influenza virus; Influenza viruses; Neutralization; Pandemics; Patient outcomes; Peptides; Phagocytosis; Proteins; vaccine; Vaccines; Viral antibodies; Viral infections; Viruses; Japan; United States > US; influenza virus; vaccine; antibody-dependent cellular cytotoxicity; antibody-dependent cellular phagocytosis

Background: Current influenza A vaccines primarily induce neutralizing antibodies targeting the variable hemagglutinin (HA) head domain, limiting their effectiveness against diverse or emerging influenza A virus (IAV) subtypes. The conserved HA stem domain, particularly the long α-helix (LAH) epitop...