A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration
Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS...
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| Published in | The Plant cell Vol. 29; no. 5; pp. 1073 - 1087 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society of Plant Biologists
01.05.2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1040-4651 1532-298X 1532-298X |
| DOI | 10.1105/tpc.16.00863 |
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| Abstract | Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in
We found that WUS-positive (WUS
) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the
locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate
expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of
. |
|---|---|
| AbstractList | The removal of repressive histone marks in a cytokinin-rich environment primes de novo activation of WUSCHEL by B-type ARABIDOPSIS RESPONSE REGULATORs and HD-ZIP III transcription factors. Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in Arabidopsis thaliana. We found that WUS-positive (WUS+) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the WUS locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate WUS expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of WUS. Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in Arabidopsis thaliana We found that WUS-positive (WUS+) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the WUS locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate WUS expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of WUS.Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in Arabidopsis thaliana We found that WUS-positive (WUS+) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the WUS locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate WUS expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of WUS. The removal of repressive histone marks in a cytokinin-rich environment primes de novo activation of WUSCHEL by B-type ARABIDOPSIS RESPONSE REGULATORs and HD-ZIP III transcription factors. Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in Arabidopsis thaliana . We found that WUS-positive (WUS + ) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the WUS locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate WUS expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of WUS . Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in We found that WUS-positive (WUS ) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of . |
| Author | Zhang, Tian-Qi Lian, Heng Wang, Jia-Wei Zhou, Chuan-Miao Xu, Lin Jiao, Yuling |
| Author_xml | – sequence: 1 givenname: Tian-Qi orcidid: 0000-0001-8000-4770 surname: Zhang fullname: Zhang, Tian-Qi organization: National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P.R. China, University of Chinese Academy of Sciences, Shanghai 200032, P.R. China – sequence: 2 givenname: Heng orcidid: 0000-0003-0522-7290 surname: Lian fullname: Lian, Heng organization: National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P.R. China – sequence: 3 givenname: Chuan-Miao surname: Zhou fullname: Zhou, Chuan-Miao organization: National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P.R. China – sequence: 4 givenname: Lin orcidid: 0000-0003-4718-1286 surname: Xu fullname: Xu, Lin organization: National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P.R. China – sequence: 5 givenname: Yuling orcidid: 0000-0002-1189-1676 surname: Jiao fullname: Jiao, Yuling organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, P.R. China, National Center for Plant Gene Research, Beijing 100101, P.R. China – sequence: 6 givenname: Jia-Wei orcidid: 0000-0003-3885-6296 surname: Wang fullname: Wang, Jia-Wei organization: National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P.R. China, ShanghaiTech University, Shanghai 200031, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28389585$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2017 American Society of Plant Biologists. All rights reserved. Copyright American Society of Plant Biologists May 2017 2017 American Society of Plant Biologists. All rights reserved. 2017 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantcell.org) is: Jia-Wei Wang (jwwang@sibs.ac.cn). www.plantcell.org/cgi/doi/10.1105/tpc.16.00863 |
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| Snippet | Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot... The removal of repressive histone marks in a cytokinin-rich environment primes de novo activation of WUSCHEL by B-type ARABIDOPSIS RESPONSE REGULATORs and... The removal of repressive histone marks in a cytokinin-rich environment primes de novo activation of WUSCHEL by B-type ARABIDOPSIS RESPONSE REGULATORs and... |
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| SubjectTerms | Activation Arabidopsis Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis - physiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Callus Cell cycle DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Plant - genetics Gene Expression Regulation, Plant - physiology Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism miRNA Organs Plant cells Plant Shoots - genetics Plant Shoots - metabolism Plant Shoots - physiology Regeneration Regulators Signal transduction Signaling Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism |
| Title | A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration |
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