Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists - Ambaye, Nigus D.; Gunzburg, Menachem J.; Lim, Reece C.C.; Price, John T.; Wilce, Matthew C.J.; Wilce, Jacqueline A. (Bioorganic & medicinal chemistry, 2011)
Keywords: Adapter protein; antagonists; antagonists & inhibitors; Benzopyrazines; binding capacity; blood; breast neoplasms; calorimetry; Cancer cells; Cell Division; Cell Division - drug effects; Cell Line, Tumor; Cellular growth assay; Drug Discovery; drug effects; Grb7; GRB7 Adaptor Protein; GRB7 Adaptor Protein - antagonists & inhibitors; Humans; Inhibitory Concentration 50; ITC; melting point; Melting point shift assay; migratory behavior; Models, Molecular; pharmacology; Pyrazines; Pyrazines - pharmacology; SH2 domain; signal transduction; Similarity search; Thermofluor; titration; Virtual screening; Grb7; Melting point shift assay; SH2 domain; Cellular growth assay; Adapter protein; Cancer cells; Benzopyrazines; Virtual screening; Thermofluor; ITC; Similarity search