Major antigens of Cryptosporidium parvum recognised by serum antibodies from different infected animal species and man
Serum humoral immune response to Cryptosporidium parvum was evaluated in six species: mouse, rabbit, lamb, calf, pig and man. Electrophoretic and immunoblot analysis showed that specific animal antibody response appeared between Day 4 and Day 15 post inoculation. The two main target antigens had app...
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Published in | Veterinary parasitology Vol. 55; no. 1-2; pp. 1 - 13 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.10.1994
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Serum humoral immune response to Cryptosporidium parvum was evaluated in six species: mouse, rabbit, lamb, calf, pig and man. Electrophoretic and immunoblot analysis showed that specific animal antibody response appeared between Day 4 and Day 15 post inoculation. The two main target antigens had apparent molecular weights of 15–17 and 23 kDa. They were recognised by each species studied. Serum IgA intensively recognised the 15–17 kDa antigen, except in rabbit. This study demonstrates that these two antigens are consistent targets of humoral immune response and can therefore be of great interest in studies of therapy/prophylaxis. |
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Bibliography: | 9501832 L72 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0304-4017 1873-2550 |
DOI: | 10.1016/0304-4017(94)90051-5 |