Self-Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction

• Published in: Scientific reports Vol. 6; no. 1; p. 29436
• Main Authors: Márquez-Miranda, Valeria, Araya-Durán, Ingrid, Camarada, María Belén, Comer, Jeffrey, Valencia-Gallegos, Jesús A, González-Nilo, Fernando Danilo
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 05.07.2016
• Subjects: Dendrimers - chemistry; Dendrimers - metabolism; Lipids - chemistry; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; RNA, Small Interfering - metabolism; Transfection

An ideal nucleic-acid transfection system should combine the physical and chemical characteristics of cationic lipids and linear polymers to decrease cytotoxicity and uptake limitations. Previous research described new types of carriers termed amphiphilic dendrimers (ADs), which are based on polyami...