High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer’s Disease Using [11C]AZD2184

• Published in: Journal of Alzheimer's disease Vol. 98; no. 4; pp. 1391 - 1401
• Main Authors: Mattsson, Patrik, Cselényi, Zsolt, Forsberg Morén, Anton, Freund-Levi, Yvonne, Wahlund, Lars-Olof, Halldin, Christer, Farde, Lars
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2024
• Subjects: Alzheimer Disease - metabolism; Aminopyridines; Amyloid beta-Peptides - metabolism; Benzothiazoles; Carbon Radioisotopes; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - metabolism; Humans; Neocortex - metabolism; Positron-Emission Tomography - methods; amyloid deposits; amygdala; Alzheimer’s disease; hippocampus; striatum; entorhinal cortex; positron emission tomography; thalamus

Background: Deposits of amyloid-β (Aβ) appear early in Alzheimer’s disease (AD). Objective: The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET). Methods: Eight cognitively unimpaired (CU) subjects, 8 with mild c...