High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer’s Disease Using [11C]AZD2184

• Published in: Journal of Alzheimer's disease Vol. 98; no. 4; pp. 1391 - 1401
• Main Authors: Mattsson, Patrik, Cselényi, Zsolt, Forsberg Morén, Anton, Freund-Levi, Yvonne, Wahlund, Lars-Olof, Halldin, Christer, Farde, Lars
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2024
• Subjects: Alzheimer Disease - metabolism; Aminopyridines; Amyloid beta-Peptides - metabolism; Benzothiazoles; Carbon Radioisotopes; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - metabolism; Humans; Neocortex - metabolism; Positron-Emission Tomography - methods; amyloid deposits; amygdala; Alzheimer’s disease; hippocampus; striatum; entorhinal cortex; positron emission tomography; thalamus
• ISSN: 1387-2877; 1875-8908
• DOI: 10.3233/JAD-231013

Background: Deposits of amyloid-β (Aβ) appear early in Alzheimer’s disease (AD). Objective: The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET). Methods: Eight cognitively unimpaired (CU) subjects, 8 with mild cognitive impairment (MCI) and 8 with mild AD were examined with PET and [11C]AZD2184. A data driven cut-point for Aβ positivity was defined by Gaussian mixture model of isocortex binding potential (BPND) values. Results: Sixteen subjects (3 CU, 5 MCI and 8 AD) were Aβ-positive. BPND was lower in subcortical and allocortical regions compared to isocortex. Fifteen of the 16 Aβ-positive subjects displayed Aβ binding in striatum, 14 in thalamus and 10 in allocortical regions. Conclusions: Aβ deposits appear to be widespread in early AD. It cannot be excluded that deposits appear simultaneously throughout the whole brain which has implications for improved diagnostics and disease monitoring.