High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer’s Disease Using [11C]AZD2184
Background: Deposits of amyloid-β (Aβ) appear early in Alzheimer’s disease (AD). Objective: The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET). Methods: Eight cognitively unimpaired (CU) subjects, 8 with mild c...
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Published in | Journal of Alzheimer's disease Vol. 98; no. 4; pp. 1391 - 1401 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London, England
SAGE Publications
01.01.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Background:
Deposits of amyloid-β (Aβ) appear early in Alzheimer’s disease (AD).
Objective:
The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET).
Methods:
Eight cognitively unimpaired (CU) subjects, 8 with mild cognitive impairment (MCI) and 8 with mild AD were examined with PET and [11C]AZD2184. A data driven cut-point for Aβ positivity was defined by Gaussian mixture model of isocortex binding potential (BPND) values.
Results:
Sixteen subjects (3 CU, 5 MCI and 8 AD) were Aβ-positive. BPND was lower in subcortical and allocortical regions compared to isocortex. Fifteen of the 16 Aβ-positive subjects displayed Aβ binding in striatum, 14 in thalamus and 10 in allocortical regions.
Conclusions:
Aβ deposits appear to be widespread in early AD. It cannot be excluded that deposits appear simultaneously throughout the whole brain which has implications for improved diagnostics and disease monitoring. |
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ISSN: | 1387-2877 1875-8908 |
DOI: | 10.3233/JAD-231013 |