Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

• Published in: Molecular cell Vol. 55; no. 3; pp. 347 - 360
• Main Authors: Riising, Eva Madi, Comet, Itys, Leblanc, Benjamin, Wu, Xudong, Johansen, Jens Vilstrup, Helin, Kristian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.08.2014
• Subjects: Animals; Cell Differentiation - genetics; Cell Differentiation - physiology; Cells, Cultured; CpG Islands; Dichlororibofuranosylbenzimidazole - pharmacology; Diterpenes - pharmacology; embryonic stem cells; Embryonic Stem Cells - metabolism; Epigenesis, Genetic; Epoxy Compounds - pharmacology; Gene Expression Regulation, Developmental - drug effects; Gene Knockout Techniques; gene silencing; Gene Silencing - drug effects; genes; Genome; genomic islands; Mice; neoplasms; Nucleosomes - genetics; Nucleosomes - metabolism; Phenanthrenes - pharmacology; Polycomb Repressive Complex 2 - metabolism; Protein Binding - genetics; Protein Binding - physiology; proteins; tissues; transcription (genetics)

Polycomb group (PcG) proteins are required for normal differentiation and development and are frequently deregulated in cancer. PcG proteins are involved in gene silencing; however, their role in initiation and maintenance of transcriptional repression is not well defined. Here, we show that knockou...