Inhibition of Glial Activation in Rostral Ventromedial Medulla Attenuates Mechanical Allodynia in a Rat Model of Cancer-induced Bone Pain

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 32; no. 2; pp. 291 - 298
• Main Author: 刘希江 卜慧莲 刘成 高峰 杨辉 田学愎 许爱军 陈治军 曹菲 田玉科
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.04.2012; Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
• Subjects: Analgesics - therapeutic use; Animal models; Animals; Arthralgia - etiology; Arthralgia - physiopathology; Arthralgia - prevention & control; astrocyte; Astrocytes; Bone; Bone Neoplasms - complications; Bone Neoplasms - drug therapy; Brain-derived neurotrophic factor; cancer-induced; Female; Glial cells; Hyperalgesia - etiology; Hyperalgesia - physiopathology; Hyperalgesia - prevention & control; Inflammation; Interleukin 1; Interleukin 6; MAP kinase; MAPK; Medicine; Medicine & Public Health; medulla; Medulla oblongata; Medulla Oblongata - pathology; Medulla Oblongata - physiopathology; Microglia; Microglia - drug effects; Microinjection; Minocycline; pain; Pain perception; Rats; Rats, Sprague-Dawley; rostral; Signal transduction; Treatment Outcome; Tumor necrosis factor- alpha; ventromedial; rostral ventromedial medulla; cancer-induced bone pain; microglia; astrocyte; p38 MAPK

Descending nociceptive modulation from the supraspinal structures plays an important role in cancer-induced bone pain (CIBP). Rostral ventromedial medulla (RVM) is a critical compo-nent of descending nociceptive facilitation circuitry, but so far the mechanisms are poorly known. In this study, we in...