Inhibition of Glial Activation in Rostral Ventromedial Medulla Attenuates Mechanical Allodynia in a Rat Model of Cancer-induced Bone Pain - 刘希江 卜慧莲 刘成 高峰 杨辉 田学愎 许爱军 陈治军 曹菲 田玉科 (Journal of Huazhong University of Science and Technology. Medical sciences, 2012)
Keywords: Analgesics - therapeutic use; Animal models; Animals; Arthralgia - etiology; Arthralgia - physiopathology; Arthralgia - prevention & control; astrocyte; Astrocytes; Bone; Bone Neoplasms - complications; Bone Neoplasms - drug therapy; Brain-derived neurotrophic factor; cancer-induced; Female; Glial cells; Hyperalgesia - etiology; Hyperalgesia - physiopathology; Hyperalgesia - prevention & control; Inflammation; Interleukin 1; Interleukin 6; MAP kinase; MAPK; Medicine; Medicine & Public Health; medulla; Medulla oblongata; Medulla Oblongata - pathology; Medulla Oblongata - physiopathology; Microglia; Microglia - drug effects; Microinjection; Minocycline; pain; Pain perception; Rats; Rats, Sprague-Dawley; rostral; Signal transduction; Treatment Outcome; Tumor necrosis factor- alpha; ventromedial; rostral ventromedial medulla; cancer-induced bone pain; microglia; astrocyte; p38 MAPK