Next-generation sequencing of BRCA1 and BRCA2 in breast cancer patients and control subjects

• Published in: Molecular and clinical oncology Vol. 2; no. 3; pp. 435 - 439
• Main Authors: BALABANSKI, LUBOMIR, ANTOV, GEORGI, DIMOVA, IVANKA, IVANOV, SAMUIL, NACHEVA, MARIA, GAVRILOV, IVAN, NESHEVA, DESISLAVA, RUKOVA, BLAGA, HADJIDEKOVA, SAVINA, MALINOV, MAXIM, TONCHEVA, DRAGA
• Format: Journal Article
• Language: English
• Published: England D.A. Spandidos 01.05.2014; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: BRCA1/BRCA2 next-generation sequencing; Breast cancer; Cell cycle; Deoxyribonucleic acid; Development and progression; DNA; DNA repair; Family medical history; Gene mutations; Genes; Genetic aspects; Genetic counseling; Genomes; Health aspects; Health risk assessment; hereditary predisposition; Mutation; Oncology; Patients; Population; Bulgaria; BRCA1/BRCA2 next-generation sequencing; breast cancer; hereditary predisposition

Breast cancer is currently the most common type of cancer in females. The majority of the hereditary forms of breast cancer are caused by mutations in the BRCA1 and BRCA2 genes, whose main function is the DNA repair of double-strand breaks. Genetic testing of females with a family history of breast...