Profiling Small RNA From Brain Extracellular Vesicles in Individuals With Depression

• Published in: The international journal of neuropsychopharmacology Vol. 27; no. 3; p. 1
• Main Authors: Ibrahim, Pascal, Denniston, Ryan, Mitsuhashi, Haruka, Yang, Jennie, Fiori, Laura M, Żurawek, Dariusz, Mechawar, Naguib, Nagy, Corina, Turecki, Gustavo
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.03.2024
• Subjects: Analysis; Brain; California; Care and treatment; Depression, Mental; Diagnosis; Ethylenediaminetetraacetic acid; Health aspects; Massachusetts; Microfluidics; MicroRNA; Mortality; Psychology, Pathological; Quebec; Regular; Canada; Massachusetts; Quebec; California; Extracellular vesicles; miRNA; depression; size exclusion chromatography; ultracentrifugation; Size exclusion chromatography; Depression; Ultracentrifugation

Abstract Background Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound par...