Profiling Small RNA From Brain Extracellular Vesicles in Individuals With Depression
Abstract Background Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound par...
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Published in | The international journal of neuropsychopharmacology Vol. 27; no. 3; p. 1 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
US
Oxford University Press
01.03.2024
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Abstract | Abstract
Background
Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound particles that can reflect the molecular signatures of the tissue of origin. We aimed to optimize a streamlined EV isolation protocol from postmortem brain tissue and determine whether EV RNA cargo, particularly microRNAs (miRNAs), have an MDD-specific profile.
Methods
EVs were isolated from postmortem human brain tissue. Quality was assessed using western blots, transmission electron microscopy, and microfluidic resistive pulse sensing. EV RNA was extracted and sequenced on Illumina platforms. Functional follow-up was performed in silico.
Results
Quality assessment showed an enrichment of EV markers, as well as a size distribution of 30 to 200 nm in diameter, and no contamination with cellular debris. Small RNA profiling indicated the presence of several RNA biotypes, with miRNAs and transfer RNAs being the most prominent. Exploring miRNA levels between groups revealed decreased expression of miR-92a-3p and miR-129-5p, which was validated by qPCR and was specific to EVs and not seen in bulk tissue. Finally, in silico functional analyses indicate potential roles for these 2 miRNAs in neurotransmission and synaptic plasticity.
Conclusion
We provide a streamlined isolation protocol that yields EVs of high quality that are suitable for molecular follow-up. Our findings warrant future investigations into brain EV miRNA dysregulation in MDD. |
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AbstractList | Background: Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound particles that can reflect the molecular signatures of the tissue of origin. We aimed to optimize a streamlined EV isolation protocol from postmortem brain tissue and determine whether EV RNA cargo, particularly microRNAs (miRNAs), have an MDD-specific profile. Methods: EVs were isolated from postmortem human brain tissue. Quality was assessed using western blots, transmission electron microscopy, and microfluidic resistive pulse sensing. EV RNA was extracted and sequenced on Illumina platforms. Functional follow-up was performed in silico. Results: Quality assessment showed an enrichment of EV markers, as well as a size distribution of 30 to 200 nm in diameter, and no contamination with cellular debris. Small RNA profiling indicated the presence of several RNA biotypes, with miRNAs and transfer RNAs being the most prominent. Exploring miRNA levels between groups revealed decreased expression of miR-92a-3p and miR-129-5p, which was validated by qPCR and was specific to EVs and not seen in bulk tissue. Finally, in silico functional analyses indicate potential roles for these 2 miRNAs in neurotransmission and synaptic plasticity. Conclusion: We provide a streamlined isolation protocol that yields EVs of high quality that are suitable for molecular follow-up. Our findings warrant future investigations into brain EV miRNA dysregulation in MDD. Keywords: Extracellular vesicles, miRNA, depression, size exclusion chromatography, ultracentrifugation Abstract Background Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound particles that can reflect the molecular signatures of the tissue of origin. We aimed to optimize a streamlined EV isolation protocol from postmortem brain tissue and determine whether EV RNA cargo, particularly microRNAs (miRNAs), have an MDD-specific profile. Methods EVs were isolated from postmortem human brain tissue. Quality was assessed using western blots, transmission electron microscopy, and microfluidic resistive pulse sensing. EV RNA was extracted and sequenced on Illumina platforms. Functional follow-up was performed in silico. Results Quality assessment showed an enrichment of EV markers, as well as a size distribution of 30 to 200 nm in diameter, and no contamination with cellular debris. Small RNA profiling indicated the presence of several RNA biotypes, with miRNAs and transfer RNAs being the most prominent. Exploring miRNA levels between groups revealed decreased expression of miR-92a-3p and miR-129-5p, which was validated by qPCR and was specific to EVs and not seen in bulk tissue. Finally, in silico functional analyses indicate potential roles for these 2 miRNAs in neurotransmission and synaptic plasticity. Conclusion We provide a streamlined isolation protocol that yields EVs of high quality that are suitable for molecular follow-up. Our findings warrant future investigations into brain EV miRNA dysregulation in MDD. Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound particles that can reflect the molecular signatures of the tissue of origin. We aimed to optimize a streamlined EV isolation protocol from post-mortem brain tissue and to determine whether EV RNA cargo, particularly microRNAs (miRNAs) have an MDD-specific profile. EVs were isolated from post-mortem human brain tissue. Quality was assessed using western blots, transmission electron microscopy, and microfluidic resistive pulse sensing. EV RNA was extracted and sequenced on Illumina platforms. Functional follow up was performed in silico. Quality assessment showed an enrichment of EV markers, as well as a size distribution of 30-200 nm in diameter, and no contamination with cellular debris. Small RNA profiling indicated the presence of several RNA biotypes, with miRNAs and transfer RNAs (tRNAs) being the most prominent. Exploring miRNA levels between groups revealed decreased expression of miR-92a-3p and miR-129-5p, which was validated by qPCR and was specific to EVs and not seen in bulk tissue. Finally, in silico functional analyses indicate potential roles for these two miRNAs in neurotransmission and synaptic plasticity. We provide a streamlined isolation protocol that yields EVs of high quality that are suitable for molecular follow up. Our findings warrant future investigations into brain EV miRNA dysregulation in MDD. BACKGROUNDMajor depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound particles that can reflect the molecular signatures of the tissue of origin. We aimed to optimize a streamlined EV isolation protocol from postmortem brain tissue and determine whether EV RNA cargo, particularly microRNAs (miRNAs), have an MDD-specific profile.METHODSEVs were isolated from postmortem human brain tissue. Quality was assessed using western blots, transmission electron microscopy, and microfluidic resistive pulse sensing. EV RNA was extracted and sequenced on Illumina platforms. Functional follow-up was performed in silico.RESULTSQuality assessment showed an enrichment of EV markers, as well as a size distribution of 30 to 200 nm in diameter, and no contamination with cellular debris. Small RNA profiling indicated the presence of several RNA biotypes, with miRNAs and transfer RNAs being the most prominent. Exploring miRNA levels between groups revealed decreased expression of miR-92a-3p and miR-129-5p, which was validated by qPCR and was specific to EVs and not seen in bulk tissue. Finally, in silico functional analyses indicate potential roles for these 2 miRNAs in neurotransmission and synaptic plasticity.CONCLUSIONWe provide a streamlined isolation protocol that yields EVs of high quality that are suitable for molecular follow-up. Our findings warrant future investigations into brain EV miRNA dysregulation in MDD. |
Audience | Academic |
Author | Mitsuhashi, Haruka Nagy, Corina Ibrahim, Pascal Żurawek, Dariusz Denniston, Ryan Yang, Jennie Mechawar, Naguib Fiori, Laura M Turecki, Gustavo |
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Cites_doi | 10.1186/s12864-018-4726-6 10.3389/fnagi.2017.00328 10.3389/fnmol.2018.00251 10.3390/ijms222111312 10.1074/jbc.M112.340513 10.1101/cshperspect.a022244 10.1172/JCI155693 10.1158/0008-5472.CAN-04-0496 10.1016/j.neuron.2020.06.002 10.1038/nbt.4183 10.1016/j.brainresbull.2023.01.002 10.1038/s41386-020-0622-2 10.3402/jev.v5.32945 10.1038/nm.4386 10.1038/s41598-021-84501-5 10.15252/embj.201695748 10.3390/genes13040562 10.1038/s41419-019-1517-1 10.1080/21655979.2021.1977767 10.1093/nar/gkab1085 10.1016/j.schres.2016.11.024 10.1093/braincomms/fcac274 10.1261/rna.064352.117 10.1038/s41380-021-01268-x 10.1186/s13229-017-0117-0 10.3389/fnmol.2014.00012 10.1016/j.pneurobio.2020.101803 10.1038/nn.3762 10.1016/j.brainresbull.2017.05.004 10.1042/BSR20192743 10.3389/fpsyt.2020.543893 10.1016/j.genrep.2021.101442 10.1038/s41593-019-0560-7 10.1093/brain/aww237 10.3390/ijms21113839 10.1016/j.psychres.2018.03.080 10.1371/journal.pone.0048814 10.1016/j.ymthe.2016.10.010 10.1074/jbc.M112.425066 10.1007/s00018-017-2595-9 10.1002/jnr.23876 10.1038/sj.emboj.7601322 10.1080/21655979.2022.2059910 10.1186/1745-6150-8-12 10.1038/srep07989 10.1093/brain/awv346 10.1016/j.bbi.2021.02.004 10.1007/s12192-020-01174-1 10.1093/schbul/sby191 10.1096/fj.201801094RR 10.1038/ncb1596 10.1038/s41398-022-02267-4 10.1038/s41598-022-19862-6 10.1007/978-1-4939-7652-2_1 10.3390/cells7120245 10.1016/j.matpr.2022.12.042 10.1113/jphysiol.2012.227868 10.21037/ncri-20-5 10.1176/appi.ajp.162.7.1375 10.1038/s41380-020-00953-7 10.1080/21655979.2022.2027061 10.1146/annurev-cellbio-101512-122326 10.1016/j.neulet.2013.06.009 10.1038/s41398-021-01746-4 10.1016/j.cell.2019.03.024 10.1093/hmg/ddt044 10.1038/s41380-021-01255-2 10.1016/j.jpsychires.2022.02.007 10.1074/jbc.M110.190009 10.1186/s13195-019-0501-4 10.1038/nrdp.2016.65 10.1016/j.bbamcr.2017.03.011 10.1016/j.neulet.2017.07.017 10.1016/j.nbd.2014.09.011 10.3389/fpsyt.2020.00392 10.1007/s00221-021-06203-8 10.1186/s12974-018-1275-5 10.1080/15384101.2020.1711578 10.1016/j.celrep.2016.06.101 10.1016/j.pnpbp.2016.06.004 10.1073/pnas.0603838103 10.3389/fncel.2018.00526 10.1093/nar/gkq635 10.1155/2018/8545347 10.1176/appi.ajp.2017.16111286 10.1016/j.jad.2015.12.061 10.15252/embr.201439668 10.1080/20013078.2017.1348885 10.1038/s41596-020-00466-1 10.3402/jev.v4.29509 |
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Keywords | Extracellular vesicles miRNA depression size exclusion chromatography ultracentrifugation Size exclusion chromatography Depression Ultracentrifugation |
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References | Fujiwara (2024031813171570100_CIT0021) 2022; 132 He (2024031813171570100_CIT0031) 2020; 40 Huang (2024031813171570100_CIT0034) 2017; 73 Linares (2024031813171570100_CIT0048) 2015; 4 Qinlin (2024031813171570100_CIT0061) 2022; 13 Gupta (2024031813171570100_CIT0028) 2022; 26 Srinivasan (2024031813171570100_CIT0071) 2019; 177 Banigan (2024031813171570100_CIT0004) 2013; 8 Konoshenko (2024031813171570100_CIT0040) 2018; 2018 Rajman (2024031813171570100_CIT0065) 2017; 36 Zhang (2024031813171570100_CIT0090) 2016; 193 Colombo (2024031813171570100_CIT0015) 2014; 30 He (2024031813171570100_CIT0030) 2017; 9 Bahrini (2024031813171570100_CIT0002) 2015; 5 Goetzl (2024031813171570100_CIT0026) 2021; 26 Jin (2024031813171570100_CIT0038) 2016; 16 Batagov (2024031813171570100_CIT0006) 2013; 8 Taguchi (2024031813171570100_CIT0073) 2018; 7 Dobricic (2024031813171570100_CIT0017) 2022; 4 Lutz (2024031813171570100_CIT0051) 2017; 174 Beurel (2024031813171570100_CIT0007) 2020; 107 Wan (2024031813171570100_CIT0080) 2020; 19 Andersen (2024031813171570100_CIT0001) 2004; 64 Chen (2024031813171570100_CIT0013) 2021; 11 Ragan (2024031813171570100_CIT0063) 2017; 183 Gabrielli (2024031813171570100_CIT0022) 2015; 16 Glaesel (2024031813171570100_CIT0025) 2020; 21 Huang (2024031813171570100_CIT0035) 2006; 25 Siedlecki-Wullich (2024031813171570100_CIT0069) 2019; 11 Chang (2024031813171570100_CIT0012) 2021; 239 Mulcahy (2024031813171570100_CIT0056) 2014; 4 Liu (2024031813171570100_CIT0049) 2017; 132 Gardiner (2024031813171570100_CIT0023) 2016; 5 Tsilioni (2024031813171570100_CIT0076) 2018; 15 Qinlin (2024031813171570100_CIT0062) 2022; 13 Trujillo-Gonzalez (2024031813171570100_CIT0075) 2019; 33 Bakhti (2024031813171570100_CIT0003) 2011; 286 Bressler (2024031813171570100_CIT0009) 2021; 26 Dumais (2024031813171570100_CIT0019) 2005; 162 Vella (2024031813171570100_CIT0078) 2017; 6 Hawley (2024031813171570100_CIT0029) 2020; 4 Meyers (2024031813171570100_CIT0053) 2017; 9 Sadik (2024031813171570100_CIT0066) 2018; 1740 Stuendl (2024031813171570100_CIT0072) 2016; 139 Morhayim (2024031813171570100_CIT0055) 2017; 1864 Perez-Boza (2024031813171570100_CIT0060) 2018; 24 Wang (2024031813171570100_CIT0081) 2012; 287 Videtic Paska (2024031813171570100_CIT0079) 2022; 13 Wei (2024031813171570100_CIT0083) 2020; 45 Schumann (2024031813171570100_CIT0068) 2017; 8 Sosanya (2024031813171570100_CIT0070) 2015; 73 Kodama (2024031813171570100_CIT0039) 2020; 23 Iguchi (2024031813171570100_CIT0036) 2016; 139 Buran (2024031813171570100_CIT0010) 2017; 656 Wu (2024031813171570100_CIT0086) 2019; 10 Giraldez (2024031813171570100_CIT0024) 2018; 36 Blair (2024031813171570100_CIT0008) 2012; 590 Zhou (2024031813171570100_CIT0091) 2022; 148 Li (2024031813171570100_CIT0046) 2020; 11 Loffreda (2024031813171570100_CIT0050) 2020; 190 Otte (2024031813171570100_CIT0058) 2016; 2 Valadi (2024031813171570100_CIT0077) 2007; 9 Crescitelli (2024031813171570100_CIT0016) 2021; 16 Saeedi (2024031813171570100_CIT0067) 2021; 26 Du (2024031813171570100_CIT0018) 2019; 45 Morgan (2024031813171570100_CIT0054) 2010; 38 Krispil-Alon (2024031813171570100_CIT0041) 2022; 12 Pascua-Maestro (2024031813171570100_CIT0096) 2018; 12 Basso (2024031813171570100_CIT0005) 2013; 288 Żurawek (2024031813171570100_CIT0093) 2021; 22 Labonte (2024031813171570100_CIT0042) 2017; 23 Munoz-Llanos (2024031813171570100_CIT0057) 2018; 11 Gross (2024031813171570100_CIT0027) 2014; 7 Ji (2024031813171570100_CIT0037) 2023; 195 Lin (2024031813171570100_CIT0047) 2021; 11 Hessvik (2024031813171570100_CIT0032) 2018; 75 Fiori (2024031813171570100_CIT0020) 2021; 26 Yeri (2024031813171570100_CIT0088) 2018; 19 Trivedi (2024031813171570100_CIT0074) 2022 Chang (2024031813171570100_CIT0011) 2013; 548 Ma (2024031813171570100_CIT0052) 2018; 265 Yasir (2024031813171570100_CIT0087) 2022; 8 Pena-Bautista (2024031813171570100_CIT0059) 2022; 12 Wang (2024031813171570100_CIT0082) 2021; 94 Lai (2024031813171570100_CIT0043) 2022; 50 World Health Organization (2024031813171570100_CIT0085) 2021 Letellier (2024031813171570100_CIT0044) 2014; 17 Hodes (2024031813171570100_CIT0033) 2017; 95 Li (2024031813171570100_CIT0045) 2017; 25 Rajendran (2024031813171570100_CIT0064) 2006; 103 Zongaro (2024031813171570100_CIT0092) 2013; 22 Chen (2024031813171570100_CIT0014) 2021; 12 Yoshino (2024031813171570100_CIT0089) 2020; 11 |
References_xml | – volume: 19 start-page: 331 year: 2018 ident: 2024031813171570100_CIT0088 article-title: Evaluation of commercially available small RNASeq library preparation kits using low input RNA publication-title: BMC Genomics doi: 10.1186/s12864-018-4726-6 contributor: fullname: Yeri – volume: 9 start-page: 328 year: 2017 ident: 2024031813171570100_CIT0030 article-title: Age-related frontal periventricular white matter hyperintensities and miR-92a-3p are associated with early-onset post-stroke depression publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2017.00328 contributor: fullname: He – volume: 11 start-page: 251 year: 2018 ident: 2024031813171570100_CIT0057 article-title: MicroRNA profiling and bioinformatics target analysis in dorsal hippocampus of chronically stressed rats: relevance to depression pathophysiology publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2018.00251 contributor: fullname: Munoz-Llanos – volume: 22 start-page: 11312 year: 2021 ident: 2024031813171570100_CIT0093 article-title: The miRNome of depression publication-title: Int J Mol Sci doi: 10.3390/ijms222111312 contributor: fullname: Żurawek – volume: 4 start-page: 3 year: 2014 ident: 2024031813171570100_CIT0056 article-title: Routes and mechanisms of extracellular vesicle uptake publication-title: J Extracell Vesicles contributor: fullname: Mulcahy – volume: 287 start-page: 21384 year: 2012 ident: 2024031813171570100_CIT0081 article-title: Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): Potential mechanism of apoptosis induction in Alzheimer disease (AD) publication-title: J Biol Chem doi: 10.1074/jbc.M112.340513 contributor: fullname: Wang – volume: 9 start-page: a022244 year: 2017 ident: 2024031813171570100_CIT0053 article-title: TGF-beta family signaling in neural and neuronal differentiation, development, and function publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a022244 contributor: fullname: Meyers – volume: 132 start-page: e155693 year: 2022 ident: 2024031813171570100_CIT0021 article-title: MicroRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance publication-title: J Clin Invest doi: 10.1172/JCI155693 contributor: fullname: Fujiwara – volume: 64 start-page: 5245 year: 2004 ident: 2024031813171570100_CIT0001 article-title: Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-0496 contributor: fullname: Andersen – volume: 107 start-page: 234 year: 2020 ident: 2024031813171570100_CIT0007 article-title: The bidirectional relationship of depression and inflammation: double trouble publication-title: Neuron doi: 10.1016/j.neuron.2020.06.002 contributor: fullname: Beurel – volume: 36 start-page: 746 year: 2018 ident: 2024031813171570100_CIT0024 article-title: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling publication-title: Nat Biotechnol doi: 10.1038/nbt.4183 contributor: fullname: Giraldez – volume: 195 start-page: 14 year: 2023 ident: 2024031813171570100_CIT0037 article-title: Exposure to enriched environment ameliorated chronic unpredictable mild stress-induced depression-like symptoms in rats via regulating the miR-92a-3p/kruppel-like factor 2 (KLF2) pathway publication-title: Brain Res Bull doi: 10.1016/j.brainresbull.2023.01.002 contributor: fullname: Ji – volume: 45 start-page: 1050 year: 2020 ident: 2024031813171570100_CIT0083 article-title: Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis publication-title: Neuropsychopharmacology doi: 10.1038/s41386-020-0622-2 contributor: fullname: Wei – volume-title: Global Health Data Exchange (GHDx) year: 2021 ident: 2024031813171570100_CIT0085 article-title: Institute of Health Metrics and Evaluation contributor: fullname: World Health Organization – volume: 5 start-page: 32945 year: 2016 ident: 2024031813171570100_CIT0023 article-title: Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey publication-title: J Extracell Vesicles doi: 10.3402/jev.v5.32945 contributor: fullname: Gardiner – volume: 23 start-page: 1102 year: 2017 ident: 2024031813171570100_CIT0042 article-title: Sex-specific transcriptional signatures in human depression publication-title: Nat Med doi: 10.1038/nm.4386 contributor: fullname: Labonte – volume: 11 start-page: 6271 year: 2021 ident: 2024031813171570100_CIT0013 article-title: Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression publication-title: Sci Rep doi: 10.1038/s41598-021-84501-5 contributor: fullname: Chen – volume: 36 start-page: 1770 year: 2017 ident: 2024031813171570100_CIT0065 article-title: A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses publication-title: EMBO J doi: 10.15252/embj.201695748 contributor: fullname: Rajman – volume: 13 start-page: 562 year: 2022 ident: 2024031813171570100_CIT0079 article-title: Suicide and changes in expression of neuronal miRNA predicted by an algorithm search through miRNA databases publication-title: Genes (Basel) doi: 10.3390/genes13040562 contributor: fullname: Videtic Paska – volume: 10 start-page: 287 year: 2019 ident: 2024031813171570100_CIT0086 article-title: MicroRNA-129 modulates neuronal migration by targeting Fmr1 in the developing mouse cortex publication-title: Cell Death Dis doi: 10.1038/s41419-019-1517-1 contributor: fullname: Wu – volume: 12 start-page: 8186 year: 2021 ident: 2024031813171570100_CIT0014 article-title: Mechanism of cargo sorting into small extracellular vesicles publication-title: Bioengineered doi: 10.1080/21655979.2021.1977767 contributor: fullname: Chen – volume: 50 start-page: D118 year: 2022 ident: 2024031813171570100_CIT0043 article-title: exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids publication-title: Nucleic Acids Res doi: 10.1093/nar/gkab1085 contributor: fullname: Lai – volume: 183 start-page: 82 year: 2017 ident: 2024031813171570100_CIT0063 article-title: Small non-coding RNA expression from anterior cingulate cortex in schizophrenia shows sex specific regulation publication-title: Schizophr Res doi: 10.1016/j.schres.2016.11.024 contributor: fullname: Ragan – volume: 4 start-page: fcac274 year: 2022 ident: 2024031813171570100_CIT0017 article-title: Common signatures of differential microRNA expression in Parkinson’s and Alzheimer’s disease brains publication-title: Brain Commun doi: 10.1093/braincomms/fcac274 contributor: fullname: Dobricic – volume: 24 start-page: 423 year: 2018 ident: 2024031813171570100_CIT0060 article-title: Exploring the RNA landscape of endothelial exosomes publication-title: RNA doi: 10.1261/rna.064352.117 contributor: fullname: Perez-Boza – volume: 26 start-page: 7355 year: 2021 ident: 2024031813171570100_CIT0026 article-title: Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder publication-title: Mol Psychiatry doi: 10.1038/s41380-021-01268-x contributor: fullname: Goetzl – volume: 8 start-page: 4 year: 2017 ident: 2024031813171570100_CIT0068 article-title: Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain publication-title: Mol Autism doi: 10.1186/s13229-017-0117-0 contributor: fullname: Schumann – volume: 7 start-page: 12 year: 2014 ident: 2024031813171570100_CIT0027 article-title: Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2014.00012 contributor: fullname: Gross – volume: 190 start-page: 101803 year: 2020 ident: 2024031813171570100_CIT0050 article-title: MiR-129-5p: a key factor and therapeutic target in amyotrophic lateral sclerosis publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2020.101803 contributor: fullname: Loffreda – volume: 17 start-page: 1040 year: 2014 ident: 2024031813171570100_CIT0044 article-title: MiR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling publication-title: Nat Neurosci doi: 10.1038/nn.3762 contributor: fullname: Letellier – volume: 132 start-page: 139 year: 2017 ident: 2024031813171570100_CIT0049 article-title: MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway publication-title: Brain Res Bull doi: 10.1016/j.brainresbull.2017.05.004 contributor: fullname: Liu – volume: 40 year: 2020 ident: 2024031813171570100_CIT0031 article-title: MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury via targeting phosphatase and tensin homolog publication-title: Biosci Rep doi: 10.1042/BSR20192743 contributor: fullname: He – volume: 11 start-page: 543893 year: 2020 ident: 2024031813171570100_CIT0089 article-title: Non-coding RNAs in psychiatric disorders and suicidal behavior publication-title: Front Psychiatry doi: 10.3389/fpsyt.2020.543893 contributor: fullname: Yoshino – volume: 26 start-page: 101442 year: 2022 ident: 2024031813171570100_CIT0028 article-title: Integrative analysis of OIP5-AS1/miR-129-5p/CREBBP axis as a potential therapeutic candidate in the pathogenesis of metal toxicity-induced Alzheimer’s disease publication-title: Gene Rep doi: 10.1016/j.genrep.2021.101442 contributor: fullname: Gupta – volume: 23 start-page: 167 year: 2020 ident: 2024031813171570100_CIT0039 article-title: Microglial microRNAs mediate sex-specific responses to tau pathology publication-title: Nat Neurosci doi: 10.1038/s41593-019-0560-7 contributor: fullname: Kodama – volume: 139 start-page: 3187 year: 2016 ident: 2024031813171570100_CIT0036 article-title: Exosome secretion is a key pathway for clearance of pathological TDP-43 publication-title: Brain doi: 10.1093/brain/aww237 contributor: fullname: Iguchi – volume: 21 start-page: 3839 year: 2020 ident: 2024031813171570100_CIT0025 article-title: MiR-129-5p and miR-130a-3p regulate VEGFR-2 expression in sensory and motor neurons during development publication-title: Int J Mol Sci doi: 10.3390/ijms21113839 contributor: fullname: Glaesel – volume: 265 start-page: 70 year: 2018 ident: 2024031813171570100_CIT0052 article-title: Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia publication-title: Psychiatry Res doi: 10.1016/j.psychres.2018.03.080 contributor: fullname: Ma – volume: 8 start-page: e48814 year: 2013 ident: 2024031813171570100_CIT0004 article-title: Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients publication-title: PLoS One doi: 10.1371/journal.pone.0048814 contributor: fullname: Banigan – volume: 25 start-page: 140 year: 2017 ident: 2024031813171570100_CIT0045 article-title: Correcting miR92a-vGAT-mediated GABAergic dysfunctions rescues human Tau-induced anxiety in mice publication-title: Mol Ther doi: 10.1016/j.ymthe.2016.10.010 contributor: fullname: Li – volume: 288 start-page: 15699 year: 2013 ident: 2024031813171570100_CIT0005 article-title: Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis publication-title: J Biol Chem doi: 10.1074/jbc.M112.425066 contributor: fullname: Basso – volume: 75 start-page: 193 year: 2018 ident: 2024031813171570100_CIT0032 article-title: Current knowledge on exosome biogenesis and release publication-title: Cell Mol Life Sci doi: 10.1007/s00018-017-2595-9 contributor: fullname: Hessvik – volume: 95 start-page: 692 year: 2017 ident: 2024031813171570100_CIT0033 article-title: Understanding the epigenetic basis of sex differences in depression publication-title: J Neurosci Res doi: 10.1002/jnr.23876 contributor: fullname: Hodes – volume: 25 start-page: 4865 year: 2006 ident: 2024031813171570100_CIT0035 article-title: CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA publication-title: EMBO J doi: 10.1038/sj.emboj.7601322 contributor: fullname: Huang – volume: 13 start-page: 9708 year: 2022 ident: 2024031813171570100_CIT0061 article-title: MiR-129-5p targets FEZ1/SCOC/ULK1/NBR1 complex to restore neuronal function in mice with post-stroke depression publication-title: Bioengineered doi: 10.1080/21655979.2022.2059910 contributor: fullname: Qinlin – volume: 8 start-page: 12 year: 2013 ident: 2024031813171570100_CIT0006 article-title: Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3’-untranslated regions publication-title: Biol Direct doi: 10.1186/1745-6150-8-12 contributor: fullname: Batagov – volume: 5 start-page: 7989 year: 2015 ident: 2024031813171570100_CIT0002 article-title: Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia publication-title: Sci Rep doi: 10.1038/srep07989 contributor: fullname: Bahrini – volume: 139 start-page: 481 year: 2016 ident: 2024031813171570100_CIT0072 article-title: Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies publication-title: Brain doi: 10.1093/brain/awv346 contributor: fullname: Stuendl – volume: 94 start-page: 225 year: 2021 ident: 2024031813171570100_CIT0082 article-title: Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2021.02.004 contributor: fullname: Wang – volume: 26 start-page: 253 year: 2021 ident: 2024031813171570100_CIT0009 article-title: Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK) publication-title: Cell Stress Chaperones doi: 10.1007/s12192-020-01174-1 contributor: fullname: Bressler – volume: 45 start-page: 1257 year: 2019 ident: 2024031813171570100_CIT0018 article-title: Genome-wide, integrative analysis implicates exosome-derived microrna dysregulation in schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/sby191 contributor: fullname: Du – volume: 33 start-page: 3601 year: 2019 ident: 2024031813171570100_CIT0075 article-title: MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex publication-title: FASEB J doi: 10.1096/fj.201801094RR contributor: fullname: Trujillo-Gonzalez – volume: 9 start-page: 654 year: 2007 ident: 2024031813171570100_CIT0077 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat Cell Biol doi: 10.1038/ncb1596 contributor: fullname: Valadi – volume: 12 start-page: 503 year: 2022 ident: 2024031813171570100_CIT0041 article-title: Sex-specific roles of hippocampal microRNAs in stress vulnerability and resilience publication-title: Transl Psychiatry doi: 10.1038/s41398-022-02267-4 contributor: fullname: Krispil-Alon – volume: 12 start-page: 15589 year: 2022 ident: 2024031813171570100_CIT0059 article-title: Plasma microRNAs as potential biomarkers in early Alzheimer disease expression publication-title: Sci Rep doi: 10.1038/s41598-022-19862-6 contributor: fullname: Pena-Bautista – volume: 1740 start-page: 1 year: 2018 ident: 2024031813171570100_CIT0066 article-title: Extracellular RNAs: A new awareness of old perspectives publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-7652-2_1 contributor: fullname: Sadik – volume: 7 start-page: 245 year: 2018 ident: 2024031813171570100_CIT0073 article-title: Exploring microRNA biomarkers for Parkinson’s disease from mRNA expression profiles publication-title: Cells doi: 10.3390/cells7120245 contributor: fullname: Taguchi – year: 2022 ident: 2024031813171570100_CIT0074 article-title: Identification of Hsa-miR-92a-3p as a novel biomarker and PIK3R1 as a key regulatory gene to combat with the diagnostic patterns of autism spectrum disorders publication-title: Mater Today Proc doi: 10.1016/j.matpr.2022.12.042 contributor: fullname: Trivedi – volume: 590 start-page: 1017 year: 2012 ident: 2024031813171570100_CIT0008 article-title: PTEN: a new player controlling structural and functional synaptic plasticity publication-title: J Physiol doi: 10.1113/jphysiol.2012.227868 contributor: fullname: Blair – volume: 4 start-page: 7 year: 2020 ident: 2024031813171570100_CIT0029 article-title: MiR-129-5p: a novel therapeutic target for amyotrophic lateral sclerosis publication-title: Noncod RNA Investig doi: 10.21037/ncri-20-5 contributor: fullname: Hawley – volume: 162 start-page: 1375 year: 2005 ident: 2024031813171570100_CIT0019 article-title: Is violent method of suicide a behavioral marker of lifetime aggression publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.162.7.1375 contributor: fullname: Dumais – volume: 26 start-page: 4191 year: 2021 ident: 2024031813171570100_CIT0020 article-title: MiR-323a regulates ERBB4 and is involved in depression publication-title: Mol Psychiatry doi: 10.1038/s41380-020-00953-7 contributor: fullname: Fiori – volume: 13 start-page: 3582 year: 2022 ident: 2024031813171570100_CIT0062 article-title: Differential expression analysis of microRNAs and mRNAs in the mouse hippocampus of post-stroke depression (PSD) based on transcriptome sequencing publication-title: Bioengineered doi: 10.1080/21655979.2022.2027061 contributor: fullname: Qinlin – volume: 30 start-page: 255 year: 2014 ident: 2024031813171570100_CIT0015 article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles publication-title: Annu Rev Cell Dev Biol doi: 10.1146/annurev-cellbio-101512-122326 contributor: fullname: Colombo – volume: 548 start-page: 190 year: 2013 ident: 2024031813171570100_CIT0011 article-title: Exosomes of BV-2 cells induced by alpha-synuclein: important mediator of neurodegeneration in PD publication-title: Neurosci Lett doi: 10.1016/j.neulet.2013.06.009 contributor: fullname: Chang – volume: 11 start-page: 629 year: 2021 ident: 2024031813171570100_CIT0047 article-title: Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder publication-title: Transl Psychiatry doi: 10.1038/s41398-021-01746-4 contributor: fullname: Lin – volume: 177 start-page: 446 year: 2019 ident: 2024031813171570100_CIT0071 article-title: Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation publication-title: Cell doi: 10.1016/j.cell.2019.03.024 contributor: fullname: Srinivasan – volume: 22 start-page: 1971 year: 2013 ident: 2024031813171570100_CIT0092 article-title: The 3’ UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse publication-title: Hum Mol Genet doi: 10.1093/hmg/ddt044 contributor: fullname: Zongaro – volume: 26 start-page: 7417 year: 2021 ident: 2024031813171570100_CIT0067 article-title: Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response publication-title: Mol Psychiatry doi: 10.1038/s41380-021-01255-2 contributor: fullname: Saeedi – volume: 148 start-page: 293 year: 2022 ident: 2024031813171570100_CIT0091 article-title: A new perspective on depression and neuroinflammation: non-coding RNA publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2022.02.007 contributor: fullname: Zhou – volume: 286 start-page: 787 year: 2011 ident: 2024031813171570100_CIT0003 article-title: Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles publication-title: J Biol Chem doi: 10.1074/jbc.M110.190009 contributor: fullname: Bakhti – volume: 11 start-page: 46 year: 2019 ident: 2024031813171570100_CIT0069 article-title: Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease publication-title: Alzheimers Res Ther doi: 10.1186/s13195-019-0501-4 contributor: fullname: Siedlecki-Wullich – volume: 2 year: 2016 ident: 2024031813171570100_CIT0058 article-title: Major depressive disorder publication-title: Nature Reviews Disease Primers doi: 10.1038/nrdp.2016.65 contributor: fullname: Otte – volume: 1864 start-page: 1133 year: 2017 ident: 2024031813171570100_CIT0055 article-title: Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing publication-title: Biochim Biophys Acta Mol Cell Res doi: 10.1016/j.bbamcr.2017.03.011 contributor: fullname: Morhayim – volume: 656 start-page: 51 year: 2017 ident: 2024031813171570100_CIT0010 article-title: Treatment with TREK1 and TRPC3/6 ion channel inhibitors upregulates microRNA expression in a mouse model of chronic mild stress publication-title: Neurosci Lett doi: 10.1016/j.neulet.2017.07.017 contributor: fullname: Buran – volume: 73 start-page: 96 year: 2015 ident: 2024031813171570100_CIT0070 article-title: Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2014.09.011 contributor: fullname: Sosanya – volume: 11 start-page: 392 year: 2020 ident: 2024031813171570100_CIT0046 article-title: Circular RNA in schizophrenia and depression publication-title: Front Psychiatry doi: 10.3389/fpsyt.2020.00392 contributor: fullname: Li – volume: 239 start-page: 3359 year: 2021 ident: 2024031813171570100_CIT0012 article-title: MiR-129-5p prevents depressive-like behaviors by targeting MAPK1 to suppress inflammation publication-title: Exp Brain Res doi: 10.1007/s00221-021-06203-8 contributor: fullname: Chang – volume: 15 start-page: 239 year: 2018 ident: 2024031813171570100_CIT0076 article-title: Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1beta publication-title: J Neuroinflammation doi: 10.1186/s12974-018-1275-5 contributor: fullname: Tsilioni – volume: 19 start-page: 419 year: 2020 ident: 2024031813171570100_CIT0080 article-title: LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy publication-title: Cell Cycle doi: 10.1080/15384101.2020.1711578 contributor: fullname: Wan – volume: 16 start-page: 1653 year: 2016 ident: 2024031813171570100_CIT0038 article-title: MiR-17-92 cluster regulates adult hippocampal neurogenesis, anxiety, and depression publication-title: Cell Rep doi: 10.1016/j.celrep.2016.06.101 contributor: fullname: Jin – volume: 73 start-page: 73 year: 2017 ident: 2024031813171570100_CIT0034 article-title: The link between long noncoding RNAs and depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2016.06.004 contributor: fullname: Huang – volume: 103 start-page: 11172 year: 2006 ident: 2024031813171570100_CIT0064 article-title: Alzheimer’s disease beta-amyloid peptides are released in association with exosomes publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0603838103 contributor: fullname: Rajendran – volume: 8 start-page: 573 year: 2022 ident: 2024031813171570100_CIT0087 article-title: Evaluation the protective effect of zinc supplementation on depression and Mir 129-GPR39 gene expression in the hippocampus of diabetic rat publication-title: Tob Regul Sci contributor: fullname: Yasir – volume: 12 start-page: 526 year: 2018 ident: 2024031813171570100_CIT0096 article-title: Extracellular vesicles secreted by astroglial cells transport apolipoprotein D to neurons and mediate neuronal survival upon oxidative stress publication-title: Front Cell Neurosci doi: 10.3389/fncel.2018.00526 contributor: fullname: Pascua-Maestro – volume: 38 start-page: 7698 year: 2010 ident: 2024031813171570100_CIT0054 article-title: CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3’-UTRs publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq635 contributor: fullname: Morgan – volume: 2018 start-page: 8545347 year: 2018 ident: 2024031813171570100_CIT0040 article-title: Isolation of extracellular vesicles: general methodologies and latest trends publication-title: Biomed Res Int doi: 10.1155/2018/8545347 contributor: fullname: Konoshenko – volume: 174 start-page: 1185 year: 2017 ident: 2024031813171570100_CIT0051 article-title: Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2017.16111286 contributor: fullname: Lutz – volume: 193 start-page: 51 year: 2016 ident: 2024031813171570100_CIT0090 article-title: Clinical predictor and circulating microRNA profile expression in patients with early onset post-stroke depression publication-title: J Affect Disord doi: 10.1016/j.jad.2015.12.061 contributor: fullname: Zhang – volume: 16 start-page: 213 year: 2015 ident: 2024031813171570100_CIT0022 article-title: Active endocannabinoids are secreted on extracellular membrane vesicles publication-title: EMBO Rep doi: 10.15252/embr.201439668 contributor: fullname: Gabrielli – volume: 6 start-page: 1348885 year: 2017 ident: 2024031813171570100_CIT0078 article-title: A rigorous method to enrich for exosomes from brain tissue publication-title: J Extracell Vesicles doi: 10.1080/20013078.2017.1348885 contributor: fullname: Vella – volume: 16 start-page: 1548 year: 2021 ident: 2024031813171570100_CIT0016 article-title: Isolation and characterization of extracellular vesicle subpopulations from tissues publication-title: Nat Protoc doi: 10.1038/s41596-020-00466-1 contributor: fullname: Crescitelli – volume: 4 start-page: 29509 year: 2015 ident: 2024031813171570100_CIT0048 article-title: High-speed centrifugation induces aggregation of extracellular vesicles publication-title: J Extracell Vesicles doi: 10.3402/jev.v4.29509 contributor: fullname: Linares |
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Background
Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of... Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD,... Background: Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the... BACKGROUNDMajor depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the... |
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SubjectTerms | Analysis Brain California Care and treatment Depression, Mental Diagnosis Ethylenediaminetetraacetic acid Health aspects Massachusetts Microfluidics MicroRNA Mortality Psychology, Pathological Quebec Regular |
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Title | Profiling Small RNA From Brain Extracellular Vesicles in Individuals With Depression |
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