Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia

• Published in: Molecular psychiatry Vol. 6; no. 2; pp. 173 - 178
• Main Authors: MILLAR, J. K, CHRISTIE, S, ANDERSON, S, LAWSON, D, LOH, D. Hsiao-Wei, DEVON, R. S, ARVEILER, B, MUIR, W. J, BLACKWOOD, D. H. R, PORTEOUS, D. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.2001
• Subjects: Adult and adolescent clinical studies; Alternative splicing; Antisense DNA; Biological and medical sciences; Cell Line; Chromosome 1; Chromosome mapping; Chromosomes; Cloning; Cosmids; Disc1 protein; Exons; Genes; Genetic aspects; Genetic Linkage; Genetic Markers; Genetics; Genome, Human; Genomes; Genomics; Hospitals; Humans; In Situ Hybridization, Fluorescence; Introns; Localization; Medical sciences; Mental disorders; Methods; Molecular Sequence Data; Nerve Tissue Proteins - genetics; Nucleotides; Proteins; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Risk factors; RNA Splice Sites - genetics; Schizophrenia; Schizophrenia - genetics; Translocation (Genetics); Translocation, Genetic; France; United Kingdom; United Kingdom > UK; Scotland; Psychosis; Human; Translocation; Linkage; Pathophysiology; Chromosome A1; Schizophrenia; Genetics

Two overlapping and antiparallel genes on chromosome 1, Disrupted In Schizophrenia 1 and 2 (DISC1 and DISC2), are disrupted by a (1;11)(q42.1;q14.3) translocation which segregates with schizophrenia through at least four generations of a large Scottish family. Consequently, these genes are worthy of...