A patent review on efficient strategies for the total synthesis of pazopanib, regorafenib and lenvatinib as novel anti-angiogenesis receptor tyrosine kinase inhibitors for cancer therapy

• Published in: Molecular diversity Vol. 26; no. 5; pp. 2981 - 3002
• Main Authors: Shiri, Pezhman, Ramezanpour, Sorour, Amani, Ali Mohammad, Dehaen, Wim
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2022; Springer Nature B.V
• Subjects: Angiogenesis; Biochemistry; Biomedical and Life Sciences; Inhibitor drugs; Kinases; Life Sciences; Organic Chemistry; Pharmacy; Polymer Sciences; Short Review; Targeted cancer therapy; Regorafenib; Lenvatinib; Cancer therapy; Total synthesis; Anti-angiogenesis receptor tyrosine kinase inhibitors; Pazopanib

Angiogenesis is an important and interesting scientific subject in the area of malignant tumours. Current research importance and interest are directed in connection to blood microvessels in cancer cell proliferation, tumour growth, and metastasis. Tyrosine kinases have been intensely implicated as...