miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes

• Published in: Journal of endocrinological investigation Vol. 43; no. 4; pp. 451 - 459
• Main Authors: Parrizas, M., Mundet, X., Castaño, C., Canivell, S., Cos, X., Brugnara, L., Giráldez-García, C., Regidor, E., Mata-Cases, M., Franch-Nadal, J., Novials, A.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2020; Springer Nature B.V
• Subjects: Aged; Biomarkers; Biomarkers - blood; Blood glucose; Blood Glucose - metabolism; Cell-Derived Microparticles - metabolism; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Disease Progression; Endocrinology; Female; Humans; Insulin; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; MicroRNAs - metabolism; Middle Aged; miRNA; Morbidity; Original Article; Prediabetic State - blood; Signal transduction; Therapeutic applications; Progression; Biomarker; MicroRNA; Diagnosis; Prediabetes; Microvesicle

Purpose Type 2 diabetes frequently remains undiagnosed for years, whereas early detection of affected individuals would facilitate the implementation of timely and cost-effective therapies, hence decreasing morbidity. With the intention of identifying novel diagnostic biomarkers, we characterized th...