A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function

• Published in: Clinical journal of the American Society of Nephrology Vol. 6; no. 8; pp. 1887 - 1894
• Main Authors: Kanbay, Mehmet, Huddam, Bulent, Azak, Alper, Solak, Yalcin, Kadioglu, Gulay Kocak, Kirbas, Ismail, Duranay, Murat, Covic, Adrian, Johnson, Richard J.
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.08.2011
• Series: Original Articles
• Subjects: Adult; Allopurinol - therapeutic use; Analysis of Variance; Asymptomatic Diseases; Biomarkers - blood; Biomarkers - urine; Blood Pressure - drug effects; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein - metabolism; Creatinine - urine; Endothelium, Vascular - diagnostic imaging; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Glomerular Filtration Rate - drug effects; Humans; Hyperuricemia - blood; Hyperuricemia - complications; Hyperuricemia - drug therapy; Hyperuricemia - physiopathology; Hyperuricemia - urine; Inflammation Mediators - blood; Kidney - drug effects; Kidney - physiopathology; Male; Middle Aged; Original; Prospective Studies; Proteinuria - etiology; Regression Analysis; Time Factors; Treatment Outcome; Turkey; Ultrasonography; Uric Acid - blood; Vasodilation - drug effects

Endothelial dysfunction is an early manifestation of vascular injury and contributes to the development of atherosclerotic cardiovascular disease. Recent studies have implicated hyperuricemia as a risk factor for cardiovascular disease. We hypothesized that lowering uric acid in subjects with asympt...