Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress

• Published in: Nature reviews. Rheumatology Vol. 20; no. 1; pp. 48 - 62
• Main Authors: Lu, Xin, Peng, Qinglin, Wang, Guochun
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.01.2024
• Subjects: Antibodies; Autoantibodies; Biomarkers; Cell activation; Dermatomyositis; Dermatomyositis - complications; Ferritin; Humans; Interferon-Induced Helicase, IFIH1; Leukocytes (neutrophilic); Lung diseases; Lung Diseases, Interstitial - diagnosis; Lung Diseases, Interstitial - etiology; Lymphocytes B; Lymphocytes T; Lymphopenia; Macrophages; Melanoma; Pathogenesis; Pathophysiology; Patients; Prognosis; Retrospective Studies; Serum levels

Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis. Although the aetiology and pathology remain unclear, increasing evidence suggests that viral infection is a potential trigger of MDA5-DM. Multiple factors, including...