CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons

• Published in: Neurochemical research Vol. 44; no. 9; pp. 2215 - 2229
• Main Authors: Deftu, Antonia Teona, Ciorescu, Ruxandra, Gheorghe, Roxana-Olimpia, Mihăilescu, Dan, Ristoiu, Violeta
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2019; Springer Nature B.V
• Subjects: Animals; Axons; Axons - drug effects; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell culture; Central nervous system; Chemokine CXCL1 - pharmacology; Chemokine CXCL2 - pharmacology; Chemokines; CXCR2 protein; Dorsal root ganglia; Ganglia; Ganglia, Spinal - cytology; Injuries; Ligands; Male; Nervous system; Neurochemistry; Neurogenesis; Neurology; Neuronal Outgrowth - drug effects; Neurons; Neurons - drug effects; Neurosciences; Original Paper; Peripheral nerves; Peripheral nervous system; Rats, Wistar; Regrowth; Therapeutic applications; Time dependence; Axon growth; Chemokine (C-X-C motif) ligand 2; Chemokine (C-X-C motif) ligand 1; Dorsal root ganglia neurons

The ability to regrow their axons after an injury is a hallmark of neurons in peripheral nervous system which distinguish them from central nervous system neurons. This ability is influenced by their intrinsic capacity to regrow and by the extracellular environment which needs to be supportive of re...