Staphylococcus aureus impairs sinonasal epithelial repair: Effects in patients with chronic rhinosinusitis with nasal polyps and control subjects

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 2; pp. 591 - 603.e3
• Main Authors: Valera, Fabiana C.P., Ruffin, Manon, Adam, Damien, Maillé, Émilie, Ibrahim, Badr, Berube, Julie, Rousseau, Simon, Brochiero, Emmanuelle, Desrosiers, Martin Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2019; Elsevier
• Subjects: Adult; Aged; Amides - pharmacology; Cells, Cultured; Chronic Disease; chronic rhinosinusitis; Cytoskeleton - metabolism; Humans; lamellipodia; Life Sciences; Male; Middle Aged; nasal epithelial cells; Nasal Polyps - immunology; Paranasal Sinuses - microbiology; Paranasal Sinuses - pathology; Pyridines - pharmacology; repair; Respiratory Mucosa - pathology; Respiratory Mucosa - physiology; Rhinitis - immunology; Rho-associated coiled-coil kinase inhibitor; rho-Associated Kinases - metabolism; Sinusitis - immunology; Staphylococcal Infections - immunology; Staphylococcus aureus; Staphylococcus aureus - physiology; Wound Healing; Y-27632; repair; ROCK; ESS; CRS; Rho-associated coiled-coil kinase inhibitor; lamellipodia; pNEC; CRSwNP; SAinactive; Y-27632; LB; chronic rhinosinusitis; nasal epithelial cells; Staphylococcus aureus

The effect of Staphylococcus aureus on nasal epithelial repair has never been assessed in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to determine whether (1) nasal epithelial cell cultures from patients with CRSwNP and control subjects repair differently; (2) S...