An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices - Alsafadi, Hani N.; Staab-Weijnitz, Claudia A.; Lehmann, Mareike; Lindner, Michael; Peschel, Britta; Königshoff, Melanie; Wagner, Darcy E. (American journal of physiology. Lung cellular and molecular physiology, 2017)
Keywords: Aged; Alveolar Epithelial Cells - metabolism; Alveolar Epithelial Cells - pathology; Alveoli; Biomarkers - metabolism; Collagen (type I); Collagen Type I - metabolism; Connective tissue growth factor; Enzyme-linked immunosorbent assay; Epithelium; Explants; Extracellular matrix; Extracellular Matrix - metabolism; Female; Fibrosis; Gene expression; Growth factors; Histology; Humans; Idiopathic Pulmonary Fibrosis - pathology; Immunofluorescence; Inflammation Mediators - metabolism; Lung - pathology; Lung diseases; Lungs; Lysophosphatidic acid; Male; Matrilysin; Matrix; Models, Biological; Molecular modelling; Molecules; Morbidity; Platelet-derived growth factor; Protein C; Proteins; Pulmonary fibrosis; Scars; Surfactant protein C; Tissue Survival; Tissues; Transforming growth factor; Transforming growth factor-b; Tumor necrosis factor-α; Up-Regulation; precision-cut lung slices; fibrosis; idiopathic pulmonary fibrosis; ex vivo; disease model