New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms - Kodama, Roberto T.; Cajado-Carvalho, Daniela; Kuniyoshi, Alexandre K.; Kitano, Eduardo S.; Tashima, Alexandre K.; Barna, Barbara F.; Takakura, Ana Carolina; Serrano, Solange M.T.; Dias-Da-Silva, Wilmar; Tambourgi, Denise V.; Portaro, Fernanda V. (Biochimica et biophysica acta, 2015)
Keywords: Africa; angiotensin I; Angiotensin-converting enzyme (ACE); angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - chemical synthesis; Angiotensin-Converting Enzyme Inhibitors - isolation & purification; Angiotensin-Converting Enzyme Inhibitors - toxicity; Animals; antihypertensive effect; Arterial Pressure - drug effects; Bitis; Bitis arietans; bradykinin; Bradykinin-potentiating peptide (BPP); Chromatography, High Pressure Liquid; Fluorescence Resonance Energy Transfer; Heart Rate - drug effects; Hypotension; Hypotension - chemically induced; Hypotension - physiopathology; in vitro studies; in vivo studies; Male; mass spectrometry; oligopeptides; Oligopeptides - chemical synthesis; Oligopeptides - isolation & purification; Oligopeptides - toxicity; peptidyl-dipeptidase A; Proline; Proline-rich oligopeptide (PRO); Rats, Wistar; Renin-Angiotensin System - drug effects; snakes; synthetic peptides; tachycardia; Tachycardia - chemically induced; Tachycardia - physiopathology; Tandem Mass Spectrometry; Venom; venoms; Viper Venoms - chemistry; Viper Venoms - toxicity; Africa; Bradykinin-potentiating peptide (BPP); Bitis; Angiotensin-converting enzyme (ACE); Venom; Hypotension; Proline-rich oligopeptide (PRO)