DNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation

• Published in: Human molecular genetics Vol. 23; no. 5; pp. 1224 - 1236
• Main Authors: Bala Tannan, Neeta, Brahmachary, Manisha, Garg, Paras, Borel, Christelle, Alnefaie, Randah, Watson, Corey T., Thomas, N. Simon, Sharp, Andrew J.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2014
• Subjects: Chromosomes, Human; Chromosomes, Human, X; DNA Methylation; Gene Silencing; Genes, X-Linked; Humans; Long Interspersed Nucleotide Elements; Nucleotide Motifs; Translocation, Genetic; X Chromosome Inactivation

X chromosome inactivation (XCI) is an epigenetic mechanism that silences the majority of genes on one X chromosome in females. Previous studies have suggested that the spread of XCI might be facilitated in part by common repeats such as long interspersed nuclear elements (LINEs). However, owing to t...