FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

• Published in: Clinical cancer research Vol. 20; no. 12; pp. 3299 - 3309
• Main Authors: WYNES, Murry W, HINZ, Trista K, DZIADZIUSZKO, Rafal, JASSEM, Jacek, WOJTYLAK, Szymon, SEJDA, Aleksandra, GOZGIT, Joseph M, BUNN, Paul A, CAMIDGE, D. Ross, TAN, Aik-Choon, HIRSCH, Fred R, HEASLEY, Lynn E, DEXIANG GAO, MARTINI, Michael, MAREK, Lindsay A, WARE, Kathryn E, EDWARDS, Michael G, BÖHM, Diana, PERNER, Sven, HELFRICH, Barbara A
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.06.2014
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Biological and medical sciences; Blotting, Western; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Cell Proliferation; Cohort Studies; Drug Resistance, Neoplasm - genetics; Follow-Up Studies; Gene Amplification; Gene Dosage; Humans; Imidazoles - pharmacology; Immunoenzyme Techniques; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Medical sciences; Neoplasm Staging; Pneumology; Protein Kinase Inhibitors - pharmacology; Pyridazines - pharmacology; Real-Time Polymerase Chain Reaction; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Signal Transduction; Tumor Cells, Cultured; Tumors of the respiratory system and mediastinum; Lung disease; Respiratory disease; Tyrosine kinase inhibitor; Copy number; Lung cancer; Biological marker; Histology; Malignant tumor; Gene expression; Bronchopulmonary; Protein; Sensitivity; Messenger RNA; Bronchus disease; Predictive factor; Fibroblast growth factor receptor 1; Cancer

FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive use of FGFR1 GCN for predicting FGFR TKI sensitivity assumes increased GCN is the only mechanism for biologically relevant increases in...