Immunogenicity of a Fourth Homologous Dose of NVX-CoV2373

• Published in: The New England journal of medicine Vol. 388; no. 9; pp. 857 - 859
• Main Authors: Alves, Katia, Plested, Joyce S., Galbiati, Shirley, Chau, Gordon, Cloney-Clark, Shane, Zhu, Mingzhu, Kalkeri, Raj, Patel, Nita, Smith, Kathy, Marcheschi, Alex, Pfeiffer, Susan, McFall, Heather, Smith, Gale, Glenn, Gregory M., Dubovsky, Filip, Mallory, Raburn M.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 02.03.2023
• Subjects: Cartography; Coronavirus; Coronaviruses; Correspondence; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Disease transmission; Humans; Immunogenicity; Immunogenicity, Vaccine - immunology; Infectious Disease; Proteins; Severe acute respiratory syndrome coronavirus 2; Software; Vaccines; Viral Infections

Boosters of adjuvanted NVX-CoV2373 protein vaccine led to increasing neutralizing titers of antibody specific for the ancestral strain and omicron variants. Whether the elicited antibodies protect against infection is unclear.