Arl1p is involved in transport of the GPI-anchored protein Gas1p from the late Golgi to the plasma membrane

• Published in: Journal of cell science Vol. 119; no. 18; pp. 3845 - 3855
• Main Authors: Liu, Ya-Wen, Lee, Szu-Wei, Lee, Fang-Jen S
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.09.2006
• Subjects: ADP-Ribosylation Factors - metabolism; Cell Membrane - metabolism; Cell Wall - metabolism; Congo Red; Gene Deletion; Glycosylphosphatidylinositols - metabolism; Golgi Apparatus - metabolism; Membrane Glycoproteins - metabolism; Membrane Proteins - metabolism; Monomeric GTP-Binding Proteins - metabolism; Protein Transport; R-SNARE Proteins - metabolism; Recombinant Fusion Proteins - metabolism; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - metabolism; Vacuoles - metabolism; Vesicular Transport Proteins - metabolism

The molecular mechanisms involved in the transport of GPI-anchored proteins from the trans-Golgi network (TGN) to the cell periphery have not been established. Arl1p is a member of the Arf-like protein (Arl) subfamily of small GTPases and is localized in the late Golgi. Although Arl1p is implicated...