Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

• Published in: International journal of molecular medicine Vol. 53; no. 5; p. 1
• Main Authors: Zhan, Yajing, Yin, Ankang, Su, Xiyang, Tang, Nan, Zhang, Zebin, Chen, Yi, Wang, Wei, Wang, Juan
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.05.2024; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Amino acids; Cell Cycle; Collaboration; Communicable diseases; Cyclin-dependent kinases; Development and progression; DNA binding proteins; DNA damage; DNA methylation; DNA replication; Gene expression; Genetic transcription; Histone Chaperones - chemistry; Histone Chaperones - genetics; Histone Chaperones - metabolism; Histones; Histones - genetics; Histones - metabolism; Humans; Kinases; Medical research; Medicine, Experimental; Molecular structure; Phosphorylation; Physiological aspects; Protein binding; Proteins; Retinoblastoma; Retinoblastoma-Binding Protein 4 - chemistry; Retinoblastoma-Binding Protein 4 - metabolism; Review; Roles; Transcription Factors - metabolism; China; RBBP7; human diseases; RBBP4; mechanism; biological function
• ISSN: 1107-3756; 1791-244X
• DOI: 10.3892/ijmm.2024.5372

Histone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones in a stable manner, ensuring the accurate and efficient execution of DNA replication, repair and transcription. Retinoblastoma binding protein (RBBP)4 and RBBP7 represent a crucial pair of histone chaperones, which not only govern the molecular behavior of histones H3 and H4, but also participate in the functions of several protein complexes, such as polycomb repressive complex 2 and nucleosome remodeling and deacetylase, thereby regulating the cell cycle, histone modifications, DNA damage and cell fate. A strong association has been indicated between RBBP4/7 and some major human diseases, such as cancer, age‑related memory loss and infectious diseases. The present review assesses the molecular mechanisms of RBBP4/7 in regulating cellular biological processes, and focuses on the variations in RBBP4/7 expression and their potential mechanisms in various human diseases, thus providing new insights for their diagnosis and treatment.