Leptin induces the generation of procoagulant, tissue factor bearing microparticles by human peripheral blood mononuclear cells - Petrini, Silvia; Neri, Tommaso; Lombardi, Stefania; Cordazzo, Cinzia; Balìa, Cristina; Scalise, Valentina; Paggiaro, Pierluigi; Pedrinelli, Roberto; Celi, Alessandro (Biochimica et biophysica acta, 2016)
Keywords: apoptosis; blood coagulation; Blood Coagulation Factors - biosynthesis; body mass index; calcium; Calcium - metabolism; calmodulin; Calmodulin - physiology; Cell-Derived Microparticles - drug effects; Cell-Derived Microparticles - physiology; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases - metabolism; flow cytometry; fluorescence; Humans; Leptin; Leptin - pharmacology; Leukocytes, Mononuclear - metabolism; Microparticles; mitogen-activated protein kinase; Monocytes; mononuclear leukocytes; Obesity; phosphatidylserines; phospholipase C; risk; risk reduction; Thromboplastin - biosynthesis; Thrombosis; Tissue factor; Type C Phospholipases - physiology; PBS; Obesity; SSc; MP; PS; [Ca2+]i; JNK; PLC; Tissue factor; CFSE; MTT; MAPK; PBMC; Thrombosis; Microparticles; TF; FITC; Monocytes; PE; Leptin; FSc; ERK