Epigenetic modifications in radiation-induced non-targeted effects and their clinical significance

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 8; p. 130386
• Main Authors: He, Xiangyang, Cai, Luwei, Tang, Haoyi, Chen, Weibo, Hu, Wentao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2023
• Subjects: Clinical Relevance; Clinical significance; Epigenesis, Genetic; Epigenetics; genetic instability; Humans; Neoplasms - genetics; Neoplasms - radiotherapy; Non-targeted effects; nucleotide sequences; Radiation; radioprotective effect; radiotherapy; Epigenetics; Clinical significance; Non-targeted effects; Radiation

Ionizing radiation (IR) plays an important role in the diagnosis and treatment of cancer. Besides the targeted effects, the non-targeted effects, which cause damage to non-irradiated cells and genomic instability in normal tissues, also play a role in the side effects of radiotherapy and have been s...