Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats

• Published in: Inflammation Vol. 42; no. 6; pp. 2181 - 2191
• Main Authors: Zhu, Yulin, Li, Shihong, Liu, Jingying, Wen, Qing, Yu, Jingui, Yu, Lingzhi, Xie, Kun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2019; Springer Nature B.V
• Subjects: Animals; Apoptosis; Autophagy; Autophagy - drug effects; Biomedical and Life Sciences; Biomedicine; Brain Injuries; Brain injury; c-Jun protein; Caspase; Caspase-3; Cerebral blood flow; Cerebral infarction; Dexmedetomidine - pharmacology; Dexmedetomidine - therapeutic use; Enzyme-linked immunosorbent assay; Gene expression; Immunology; Infarction, Middle Cerebral Artery; Inflammation; Inflammation - prevention & control; Internal Medicine; Ischemia; JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases - metabolism; JNK protein; Kinases; Latency; Learning Disabilities - drug therapy; MAP Kinase Signaling System - physiology; Memory Disorders - drug therapy; mRNA; Original Article; Pathology; Phagocytosis; Pharmacology/Toxicology; Phosphorylation; Rats; Reperfusion; Reperfusion Injury - drug therapy; Rheumatology; Signal transduction; Spatial discrimination learning; Spatial memory; Transcription factors; Transmission electron microscopy; JNK signaling pathway; Inflammation; Ischemia reperfusion injury; Autophagy; Dexmedetomidine

To investigate the effect of dexmedetomidine post-conditioning on the inflammatory response and autophagy effect of focal cerebral ischemia reperfusion injury in rats, and further to study its potential mechanisms. Water maze was conducted to evaluate spatial learning and memory ability of middle ce...