The role of calcium and vitamin D dietary intake on risk of colorectal cancer: systematic review and meta-analysis of case–control studies

Purpose The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs. Methods The artic...

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Published inCancer causes & control Vol. 33; no. 2; pp. 167 - 182
Main Authors Lopez-Caleya, Juan Francisco, Ortega-Valín, Luis, Fernández-Villa, Tania, Delgado-Rodríguez, Miguel, Martín-Sánchez, Vicente, Molina, Antonio José
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.02.2022
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Calcium
Calcium, Dietary
Cancer Research
Case-Control Studies
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Colorectal Neoplasms - prevention & control
Dietary intake
Eating
Epidemiology
Hematology
Humans
Meta-analysis
Oncology
Public Health
Review Article
Tumors
Vitamin D
Intake
Calcium
Vitamin D
Case–control study
Colorectal cancer
Meta-analysis
Online AccessGet full text

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Abstract Purpose The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs. Methods The articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019. Results There were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92–0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93–0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D. Conclusion Higher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.
AbstractList PurposeThe aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs.MethodsThe articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019. ResultsThere were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92–0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93–0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D. ConclusionHigher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.
Purpose The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs. Methods The articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019. Results There were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92–0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93–0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D. Conclusion Higher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.
The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case-control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs.PURPOSEThe aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case-control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs.The articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019.METHODSThe articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019.There were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92-0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93-0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D.RESULTSThere were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92-0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93-0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D.Higher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.CONCLUSIONHigher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.
The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case-control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs. The articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019. There were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92-0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93-0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D. Higher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.
Author Martín-Sánchez, Vicente
Lopez-Caleya, Juan Francisco
Fernández-Villa, Tania
Molina, Antonio José
Delgado-Rodríguez, Miguel
Ortega-Valín, Luis
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  surname: Ortega-Valín
  fullname: Ortega-Valín, Luis
  organization: Department of Pharmacy, Complejo Asistencial Universitario de León
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  givenname: Tania
  surname: Fernández-Villa
  fullname: Fernández-Villa, Tania
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  surname: Delgado-Rodríguez
  fullname: Delgado-Rodríguez, Miguel
  organization: Division of Preventive Medicine, University of Jaén
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  surname: Martín-Sánchez
  fullname: Martín-Sánchez, Vicente
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  givenname: Antonio José
  orcidid: 0000-0002-5948-6397
  surname: Molina
  fullname: Molina, Antonio José
  email: ajmolt@unileon.es
  organization: Faculty of Health Sciences, The Research Group in Gene—Environment and Health Interactions (GIIGAS) / Institut of Biomedicine (IBIOMED), University of Leon
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34708323$$D View this record in MEDLINE/PubMed
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Copyright The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021
2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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Issue 2
Keywords Intake
Calcium
Vitamin D
Case–control study
Colorectal cancer
Meta-analysis
Language English
License 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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PublicationSubtitle An International Journal of Studies of Cancer in Human Populations
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Snippet Purpose The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies...
The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case-control studies according to...
PurposeThe aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies...
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SubjectTerms Biomedical and Life Sciences
Biomedicine
Calcium
Calcium, Dietary
Cancer Research
Case-Control Studies
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Colorectal Neoplasms - prevention & control
Dietary intake
Eating
Epidemiology
Hematology
Humans
Meta-analysis
Oncology
Public Health
Review Article
Tumors
Vitamin D
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Title The role of calcium and vitamin D dietary intake on risk of colorectal cancer: systematic review and meta-analysis of case–control studies
URI https://link.springer.com/article/10.1007/s10552-021-01512-3
https://www.ncbi.nlm.nih.gov/pubmed/34708323
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